Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluphenazine
Drug ID BADD_D00935
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Indications and Usage For management of manifestations of psychotic disorders.
Marketing Status Discontinued; Prescription
ATC Code N05AB02
DrugBank ID DB00623
KEGG ID D07977
MeSH ID D005476
PubChem ID 3372
TTD Drug ID D0P5SA
NDC Product Code Not Available
Synonyms Fluphenazine | Flufenazin | Fluphenazine Hydrochloride | Hydrochloride, Fluphenazine | Lyogen | Prolixin
Chemical Information
Molecular Formula C22H26F3N3OS
CAS Registry Number 69-23-8
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Body temperature increased13.15.01.001--Not Available
Cardiac arrest02.03.04.001--
Catatonia19.11.01.001--Not Available
Choreoathetosis17.01.01.003--Not Available
Constipation07.02.02.001--
Corneal opacity06.06.03.005--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic10.01.04.004; 23.03.04.016--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dysphagia07.01.06.003--
Dyspnoea02.01.03.002; 22.02.01.004--
Eczema23.03.04.006--
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Extrapyramidal disorder17.01.02.007--
Glaucoma06.03.01.002--
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hepatocellular injury09.01.07.008--Not Available
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