Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluorouracil
Drug ID BADD_D00931
Description A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Indications and Usage For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Marketing Status Prescription; Discontinued
ATC Code L01BC02
DrugBank ID DB00544
KEGG ID D00584
MeSH ID D005472
PubChem ID 3385
TTD Drug ID D05LEO
NDC Product Code 63323-117; 0378-8078; 51672-4062; 16714-178; 70700-189; 51862-362; 51672-4118; 70700-186; 50090-4264; 38779-0025; 51672-4063; 0378-4791; 68001-524; 25021-215; 68001-266; 62049-185; 38779-3185; 16729-276; 68001-525; 0187-3204; 68083-269; 68083-293; 51927-1085; 68083-270; 66530-249; 28105-421; 16110-812; 68083-292; 70700-187; 0187-5200; 70700-188; 59348-0055; 12070-0002; 49452-3175; 16729-542; 0395-8080; 62991-1486
Synonyms Fluorouracil | 5FU | 5-FU | 5-Fluorouracil | 5 Fluorouracil | Fluoruracil | 5-FU Lederle | 5 FU Lederle | 5-FU Medac | 5 FU Medac | 5-HU Hexal | 5 HU Hexal | Adrucil | Carac | Efudix | Fluoro-Uracile ICN | Fluoro Uracile ICN | Efudex | Fluoroplex | Flurodex | Fluorouracil Mononitrate | Fluorouracil Monopotassium Salt | Fluorouracil Monosodium Salt | Fluorouracil Potassium Salt | Fluorouracil-GRY | Fluorouracil GRY | Fluorouracile Dakota | Dakota, Fluorouracile | Fluorouracilo Ferrer Far | Fluracedyl | Haemato-FU | Haemato FU | Neofluor | Onkofluor | Ribofluor | 5-Fluorouracil-Biosyn | 5 Fluorouracil Biosyn
Chemical Information
Molecular Formula C4H3FN2O2
CAS Registry Number 51-21-8
SMILES C1=C(C(=O)NC(=O)N1)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisSoluble TNF receptor IIP68636Not Available14614330; 15546879; 10583368
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Bone marrow toxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
Drug effect decreasedDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
NeurotoxicityDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
Toxicity to various agentsDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758909552051; 8955653; 10673535
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T7589015228171; 9893619; 12525681
VomitingDihydropyrimidine dehydrogenase [NADP(+)]Q12882T758907882316; 8248211; 8137256
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rhabdomyolysis15.05.05.002--
Rhinitis22.07.03.006; 11.01.13.004--
Scab23.03.03.0040.002352%Not Available
Scar23.03.11.008; 12.01.06.0080.000941%Not Available
Scrotal swelling21.12.02.0050.002352%Not Available
Second primary malignancy16.16.01.0140.000368%
Seizure17.12.03.001--
Sense of oppression08.01.09.0200.001411%Not Available
Sensory loss17.02.07.007--Not Available
Sepsis11.01.11.0030.002086%
Septic shock24.06.02.011; 11.01.11.0040.001718%Not Available
Shock24.06.02.0020.001411%Not Available
Sinus bradycardia02.03.03.0090.000941%
Sinusitis22.07.03.007; 11.01.13.005--
Skin erosion23.07.03.0020.000941%Not Available
Skin exfoliation23.03.07.0030.004704%Not Available
Skin fissures23.03.03.0080.000941%Not Available
Skin hyperpigmentation23.05.01.003--
Skin infection11.01.12.003; 23.09.04.0020.000941%
Skin irritation23.03.04.0090.001882%Not Available
Skin reaction23.03.03.013; 10.01.03.0190.003763%Not Available
Skin ulcer24.04.03.007; 23.07.03.0030.000941%
Sleep disorder19.02.04.001--Not Available
Small intestinal obstruction07.13.06.0010.004234%
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.0030.001882%Not Available
Splenomegaly01.09.02.0010.002823%Not Available
Squamous cell carcinoma16.16.01.0020.001411%Not Available
Stomatitis07.05.06.0050.009879%
Sudden death08.04.01.003; 02.03.04.0130.000614%
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