Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fludarabine
Drug ID BADD_D00914
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Not Available
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D07966
MeSH ID C024352
PubChem ID 657237
TTD Drug ID D0F2XQ
NDC Product Code Not Available
Synonyms fludarabine | 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- | F-ara-A | 2-fluoroadenine arabinoside | 9-beta-D-arabinofuranosyl-2-fluoroadenine
Chemical Information
Molecular Formula C10H12FN5O4
CAS Registry Number 21679-14-1
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchitis22.07.01.001; 11.01.09.001--
Bronchopulmonary aspergillosis22.07.08.001; 11.03.01.0020.000278%Not Available
C-reactive protein increased13.09.01.0070.000486%Not Available
Cardiac failure02.05.01.0010.001066%
Cardiac failure congestive02.05.01.002--Not Available
Cardiomyopathy02.04.01.0010.000533%Not Available
Cerebellar syndrome17.02.02.002--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.001066%
Cholecystitis09.03.01.0010.000533%
Cholelithiasis09.03.01.002--Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.0040.001066%Not Available
Coma17.02.09.0010.000208%Not Available
Confusional state17.02.03.005; 19.13.01.0010.002398%
Constipation07.02.02.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
Cystitis haemorrhagic20.03.02.003--Not Available
Cytomegalovirus infection11.05.01.0020.001066%
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Dehydration14.05.05.001--
Delirium19.13.02.0010.001865%
Depressed level of consciousness17.02.04.0020.000139%
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diffuse large B-cell lymphoma16.28.02.001; 01.15.02.0010.000208%Not Available
Discomfort08.01.08.003--Not Available
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