Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluconazole
Drug ID BADD_D00912
Description Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
Indications and Usage For the treatment of fungal infections.
Marketing Status Prescription; Discontinued
ATC Code D01AC15; J02AC01
DrugBank ID DB00196
KEGG ID D00322
MeSH ID D015725
PubChem ID 3365
TTD Drug ID D09LNI
NDC Product Code 51407-424; 55111-144; 51407-301; 53104-7569; 70934-783; 70985-015; 16571-210; 68071-2557; 63187-584; 63275-9960; 68071-2347; 65862-059; 50090-0869; 51686-0006; 66039-857; 63629-8970; 67405-601; 70710-1137; 16714-691; 0395-8036; 55700-945; 51407-299; 51407-302; 55154-3400; 51407-300; 53002-4198; 65862-060; 51407-425; 57237-003; 50090-4426; 51407-426; 68071-4651; 62559-990; 68462-104; 0172-5412; 0172-5410; 72189-143; 63187-096; 0143-9668; 63629-1950; 16571-211; 50090-3899; 68071-4002; 43063-642; 68071-4501; 55289-148; 71335-1268; 71335-0686; 51672-4066; 52343-087; 68071-2436; 71205-563; 70771-1065; 52343-085; 51672-4065; 50090-4425; 0049-3410; 63629-1948; 0904-6500; 38779-2442; 71335-1037; 70710-1140; 50090-2195; 55111-145; 59762-5018; 68071-2609; 57237-149; 52343-086; 71205-081; 70985-016; 16571-212; 61919-380; 51927-3783; 0049-3450; 70518-0560; 62559-993; 25021-184; 52343-088; 72789-209; 72189-149; 76420-164; 50090-5299; 70710-1138; 60760-804; 16714-696; 70518-3312; 0143-9669; 70934-935; 16714-692; 50268-339; 65862-299; 51672-4067; 71335-1511; 63629-1947; 0049-3440; 0338-6045; 50090-3194; 68084-728; 64567-0002; 59762-5017; 67405-604; 70771-1063; 65862-300; 68071-2601; 49452-3149; 59762-5016; 65427-025; 59762-5015; 72189-140; 61919-419; 57237-006; 72789-096; 51552-1031; 67405-603; 55111-039; 0904-6501; 53069-0380; 71335-0557; 60760-803; 0338-6046; 50090-4864; 65015-601; 70985-013; 62559-992; 71335-1954; 59762-5029; 70710-1139; 16714-693; 0049-3420; 71335-0764; 68788-7959; 70518-2415; 71335-1175; 68001-253; 0143-9666; 51655-435; 63629-8971; 71335-1895; 53002-4400; 63629-9091; 53002-2198; 70518-2411; 62559-991; 55111-146; 71335-1448; 65841-108; 71205-573; 68001-252; 71205-104; 51672-4064; 72189-342; 43063-645; 51407-427; 16714-695; 59762-5030; 70934-501; 71335-1948; 68462-102; 63629-7986; 55111-143; 0172-5411; 60592-209; 57237-150; 70518-3092; 62991-2651; 65862-058; 16571-213; 63187-878; 0143-9667; 67405-602; 55154-7875; 65862-061; 68462-119; 0172-5413; 63629-8749; 57237-004; 62207-008; 68788-7150; 0049-3430; 71205-283; 70985-014; 71335-0769; 70518-2087; 63629-1949; 43063-326; 0143-9899; 0049-3500; 68084-735; 68071-4386; 70771-1066; 61919-493; 71205-650; 50268-337; 70518-3111; 68001-251; 60760-113; 55700-916; 61919-333; 68788-7621; 50090-5764; 57237-005; 53104-7522; 68788-7293; 68001-254; 65862-297; 63187-613; 70771-1064; 16714-694; 53002-1198; 63629-9134; 50090-3196; 70518-3100; 55700-521; 68788-7888; 55289-824; 68462-101; 71205-094; 13371-418
Synonyms Fluconazole | Zonal | Béagyne | Diflucan | Fluc Hexal | Flucobeta | FlucoLich | Fluconazol AbZ | Fluconazol AL | Fluconazol Stada | Fluconazol von ct | Fluconazol-Isis | Fluconazol Isis | Fluconazol-ratiopharm | Fluconazol ratiopharm | Flunazul | Fungata | Lavisa | Loitin | Neofomiral | Oxifungol | Solacap | UK-49858 | UK 49858 | UK49858 | Triflucan | Apo-Fluconazole | Apo Fluconazole
Chemical Information
Molecular Formula C13H12F2N6O
CAS Registry Number 86386-73-4
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityATP-dependent bile acid permeaseP32386Not Available9797228; 12019078; 11864952; 10390213
HypersensitivityATP-dependent translocase ABCB1P08183T252589797228; 12019078; 11864952; 10390213
HypersensitivityLanosterol 14-alpha demethylaseQ8K0C4Not Available9797228; 12019078; 11864952; 10390213
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Long QT syndrome02.03.01.0170.001031%Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.0010.000412%Not Available
Lymphadenopathy01.09.01.0020.000206%Not Available
Lymphocyte count decreased13.01.06.006--
Malaise08.01.01.003--
Mass08.03.05.0030.000206%Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Meningitis cryptococcal17.06.04.001; 11.03.04.0020.000188%Not Available
Menopausal symptoms21.02.02.002--Not Available
Menorrhagia21.01.03.002--
Metrorrhagia21.01.01.0060.000619%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.0040.001237%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.000619%
Myalgia15.05.02.0010.001031%
Myelodysplastic syndrome01.10.04.001; 16.01.04.0010.000054%
Myopathy15.05.05.0010.000206%Not Available
Nail disorder23.02.05.0020.000206%
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.0100.000412%
Night sweats23.02.03.006; 08.01.03.0310.000206%Not Available
Normochromic normocytic anaemia01.03.02.0050.000206%Not Available
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