Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluconazole
Drug ID BADD_D00912
Description Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. The side effect profile of this drug is minimal. It has been demonstrated as an efficacious treatment for vaginal yeast infections in one single dose.[A174325]
Indications and Usage For the treatment of fungal infections.
Marketing Status Prescription; Discontinued
ATC Code D01AC15; J02AC01
DrugBank ID DB00196
KEGG ID D00322
MeSH ID D015725
PubChem ID 3365
TTD Drug ID D09LNI
NDC Product Code 51407-424; 55111-144; 51407-301; 53104-7569; 70934-783; 70985-015; 16571-210; 68071-2557; 63187-584; 63275-9960; 68071-2347; 65862-059; 50090-0869; 51686-0006; 66039-857; 63629-8970; 67405-601; 70710-1137; 16714-691; 0395-8036; 55700-945; 51407-299; 51407-302; 55154-3400; 51407-300; 53002-4198; 65862-060; 51407-425; 57237-003; 50090-4426; 51407-426; 68071-4651; 62559-990; 68462-104; 0172-5412; 0172-5410; 72189-143; 63187-096; 0143-9668; 63629-1950; 16571-211; 50090-3899; 68071-4002; 43063-642; 68071-4501; 55289-148; 71335-1268; 71335-0686; 51672-4066; 52343-087; 68071-2436; 71205-563; 70771-1065; 52343-085; 51672-4065; 50090-4425; 0049-3410; 63629-1948; 0904-6500; 38779-2442; 71335-1037; 70710-1140; 50090-2195; 55111-145; 59762-5018; 68071-2609; 57237-149; 52343-086; 71205-081; 70985-016; 16571-212; 61919-380; 51927-3783; 0049-3450; 70518-0560; 62559-993; 25021-184; 52343-088; 72789-209; 72189-149; 76420-164; 50090-5299; 70710-1138; 60760-804; 16714-696; 70518-3312; 0143-9669; 70934-935; 16714-692; 50268-339; 65862-299; 51672-4067; 71335-1511; 63629-1947; 0049-3440; 0338-6045; 50090-3194; 68084-728; 64567-0002; 59762-5017; 67405-604; 70771-1063; 65862-300; 68071-2601; 49452-3149; 59762-5016; 65427-025; 59762-5015; 72189-140; 61919-419; 57237-006; 72789-096; 51552-1031; 67405-603; 55111-039; 0904-6501; 53069-0380; 71335-0557; 60760-803; 0338-6046; 50090-4864; 65015-601; 70985-013; 62559-992; 71335-1954; 59762-5029; 70710-1139; 16714-693; 0049-3420; 71335-0764; 68788-7959; 70518-2415; 71335-1175; 68001-253; 0143-9666; 51655-435; 63629-8971; 71335-1895; 53002-4400; 63629-9091; 53002-2198; 70518-2411; 62559-991; 55111-146; 71335-1448; 65841-108; 71205-573; 68001-252; 71205-104; 51672-4064; 72189-342; 43063-645; 51407-427; 16714-695; 59762-5030; 70934-501; 71335-1948; 68462-102; 63629-7986; 55111-143; 0172-5411; 60592-209; 57237-150; 70518-3092; 62991-2651; 65862-058; 16571-213; 63187-878; 0143-9667; 67405-602; 55154-7875; 65862-061; 68462-119; 0172-5413; 63629-8749; 57237-004; 62207-008; 68788-7150; 0049-3430; 71205-283; 70985-014; 71335-0769; 70518-2087; 63629-1949; 43063-326; 0143-9899; 0049-3500; 68084-735; 68071-4386; 70771-1066; 61919-493; 71205-650; 50268-337; 70518-3111; 68001-251; 60760-113; 55700-916; 61919-333; 68788-7621; 50090-5764; 57237-005; 53104-7522; 68788-7293; 68001-254; 65862-297; 63187-613; 70771-1064; 16714-694; 53002-1198; 63629-9134; 50090-3196; 70518-3100; 55700-521; 68788-7888; 55289-824; 68462-101; 71205-094; 13371-418
Synonyms Fluconazole | Zonal | Béagyne | Diflucan | Fluc Hexal | Flucobeta | FlucoLich | Fluconazol AbZ | Fluconazol AL | Fluconazol Stada | Fluconazol von ct | Fluconazol-Isis | Fluconazol Isis | Fluconazol-ratiopharm | Fluconazol ratiopharm | Flunazul | Fungata | Lavisa | Loitin | Neofomiral | Oxifungol | Solacap | UK-49858 | UK 49858 | UK49858 | Triflucan | Apo-Fluconazole | Apo Fluconazole
Chemical Information
Molecular Formula C13H12F2N6O
CAS Registry Number 86386-73-4
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HypersensitivityATP-dependent bile acid permeaseP32386Not Available9797228; 12019078; 11864952; 10390213
HypersensitivityATP-dependent translocase ABCB1P08183T252589797228; 12019078; 11864952; 10390213
HypersensitivityLanosterol 14-alpha demethylaseQ8K0C4Not Available9797228; 12019078; 11864952; 10390213
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperventilation22.02.01.006; 19.01.02.0040.000206%Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia05.06.03.001; 14.06.03.0010.000825%
Hypokalaemia14.05.03.0020.001031%
Hypokinesia17.01.02.009--Not Available
Hypomagnesaemia14.04.02.0010.000412%
Hyponatraemia14.05.04.002--
Hypopnoea22.02.01.021--Not Available
Hypospadias21.15.01.003; 20.07.04.001; 03.03.01.0050.000206%Not Available
Hypotension24.06.03.0020.001444%
Hypothermia08.05.01.003; 12.05.03.0010.000206%
Hypoxia22.02.02.0030.000309%
Ileus07.13.01.001--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Intracranial pressure increased17.07.02.0020.000206%Not Available
Irritability19.04.02.013; 08.01.03.011--
Jarisch-Herxheimer reaction10.02.01.0020.000928%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000309%Not Available
Lacrimation increased06.08.02.004--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.0010.000516%Not Available
Lip oedema07.05.04.004; 23.04.01.006; 10.01.05.0040.000619%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000722%Not Available
Liver abscess11.01.18.001; 09.01.11.0010.000206%Not Available
Liver disorder09.01.08.0010.000309%Not Available
Liver function test abnormal13.03.01.0130.000412%Not Available
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