Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flecainide acetate
Drug ID BADD_D00903
Description Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone].[A186880] Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics.[A186931] It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.[L8875]
Indications and Usage Flecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin.
Marketing Status Prescription; Discontinued
ATC Code C01BC04
DrugBank ID DB01195
KEGG ID D00638
MeSH ID D005424
PubChem ID 41022
TTD Drug ID D03DAP
NDC Product Code 50268-321; 53746-642; 50090-2968; 63629-7982; 57237-065; 0054-0011; 57237-063; 14593-897; 65862-622; 53746-643; 65162-643; 65162-641; 57741-3300; 63629-7979; 72640-021; 50090-1132; 53746-641; 65571-0001; 65862-621; 65862-623; 50090-5267; 0054-0010; 50090-2233; 57237-064; 71335-1487; 50090-5306; 50268-320; 59651-123; 0054-0012; 65162-642; 53069-1020; 57741-0800
Synonyms Flecainide | Flecainide Acetate | Flecainide Monoacetate | Flecainide Monoacetate, (R)-Isomer | Flecainide Monoacetate, (S)-Isomer | Flecainide, (R)-Isomer | Flecainide, (S)-Isomer | Flecainide, 5-HO-N-(6-oxo)-Derivative | Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer | Flecatab | R818 | Tambocor | Flecadura | Flecainide Monoacetate, (+-)-Isomer | Flecainid-Isis | Flecainid Isis | Flécaïne | Apocard
Chemical Information
Molecular Formula C19H24F6N2O5
CAS Registry Number 54143-56-5
SMILES CC(=O)O.C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Granulocytopenia01.02.03.003--Not Available
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Lip swelling23.04.01.007; 07.05.04.005; 10.01.05.005--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Paresis17.01.04.008--Not Available
Photophobia17.17.02.006; 06.01.01.004--
Pneumonitis22.01.01.006--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Sinus arrest02.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
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