Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Felbamate
Drug ID BADD_D00871
Description Felbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization). Alternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites.
Indications and Usage For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use.
Marketing Status Prescription
ATC Code N03AX10
DrugBank ID DB00949
KEGG ID D00536
MeSH ID D000078328
PubChem ID 3331
TTD Drug ID D05KON
NDC Product Code 51525-0442; 51672-4185; 63629-1944; 0037-0431; 62559-731; 17381-554; 0037-0430; 65162-734; 43826-255; 47621-054; 42385-721; 51672-4172; 69988-0032; 51672-4186; 72578-056; 66689-825; 51525-0430; 46016-2542; 62559-730; 16714-775; 73223-003; 47781-630; 47781-627; 70771-1077; 63629-1937; 43826-256; 0121-0891; 72578-057; 65162-686; 0037-0442; 70771-1078; 51525-0431; 65162-735; 22365-007
Synonyms Felbamate | 2-Phenyl-1,3-propanediol dicarbamate | 2 Phenyl 1,3 propanediol dicarbamate | Taloxa | Felbatol | Felbamyl | ADD-03055 | ADD 03055 | ADD03055 | (3-Carbamoyloxy-2-phenyl-propyl) carbamate | W-554 | W 554 | W554
Chemical Information
Molecular Formula C11H14N2O4
CAS Registry Number 25451-15-4
SMILES C1=CC=C(C=C1)C(COC(=O)N)COC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450 3A4P08684T378489606477; 9314612
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chills15.05.03.016; 08.01.09.001--
Choreoathetosis17.01.01.003--Not Available
Coagulopathy01.01.02.001--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Dehydration14.05.05.001--
Delusion19.10.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disseminated intravascular coagulation01.01.02.002; 24.01.01.010--
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug interaction08.06.03.001--Not Available
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.002--
Encephalocele17.19.01.005; 03.10.02.001--Not Available
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