Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Everolimus
Drug ID BADD_D00858
Description Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Indications and Usage Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected.
Marketing Status Prescription
ATC Code L01EG02; L04AA18
DrugBank ID DB01590
KEGG ID D02714
MeSH ID D000068338
PubChem ID 6442177
TTD Drug ID D0K3QS
NDC Product Code 65727-064; 65129-1324; 0078-0626; 0078-0620; 0054-0482; 67877-719; 52076-6247; 0078-0594; 0054-0470; 49884-159; 0378-3097; 49884-158; 68254-6234; 65727-063; 49884-160; 70377-013; 71796-012; 49884-119; 0378-3098; 70225-1103; 52076-6253; 70377-010; 0078-0422; 0054-0497; 0078-0414; 0054-0471; 0378-0006; 0093-7767; 0078-0627; 52076-6234; 62227-013; 0093-7766; 0078-0628; 71052-559; 67877-720; 0378-0005; 65727-046; 49884-125; 0054-0472; 0054-0604; 0078-0566; 49884-283; 0378-0007; 67877-721; 67877-718; 51991-823; 0054-0481; 17404-1027; 0078-0417; 0078-0415; 0093-7768; 49884-127; 70377-011; 62227-018; 70377-012; 0054-0480; 62227-019; 51991-821; 51991-822; 0078-0567; 0378-3096; 51991-824
Synonyms Everolimus | SDZ RAD | RAD, SDZ | SDZ-RAD | 40-O-(2-hydroxyethyl)-rapamycin | RAD 001 | 001, RAD | RAD001 | Certican | Afinitor
Chemical Information
Molecular Formula C53H83NO14
CAS Registry Number 159351-69-6
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O) C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Metastases to meninges17.02.10.012; 16.22.02.0030.000286%Not Available
Pulmonary sepsis22.07.01.014; 11.01.11.0140.000381%Not Available
Febrile infection11.01.08.052; 08.05.02.0140.000730%Not Available
Neuroendocrine tumour16.24.01.009; 05.08.01.0130.001999%Not Available
Palatal disorder07.05.01.0190.000730%Not Available
Small intestinal haemorrhage24.07.02.019; 07.12.03.0020.000730%
Lymphangiosis carcinomatosa24.09.02.007; 16.22.02.009; 01.09.01.0270.000666%Not Available
Brain natriuretic peptide increased13.02.04.0110.000730%Not Available
Urinary tract infection bacterial20.08.02.006; 11.02.01.0240.000730%Not Available
Clostridium difficile infection11.02.02.0090.002554%Not Available
Breast cancer metastatic21.05.01.016; 16.10.01.0080.002570%Not Available
Hepatic mass09.01.08.0150.001460%Not Available
Biliary dilatation09.02.03.0040.000730%Not Available
Cell death14.11.02.005; 08.03.03.0030.000286%Not Available
Gastric varices haemorrhage24.07.02.044; 09.01.06.014; 07.12.01.0050.000730%Not Available
Computerised tomogram thorax abnormal13.19.02.0050.001095%Not Available
Biliary sepsis11.01.18.005; 09.02.01.0050.000190%Not Available
Hypertensive emergency24.08.01.0040.001095%Not Available
General physical condition abnormal13.15.01.0400.000190%Not Available
Blood chromogranin A increased13.10.02.0120.003649%Not Available
Oxygen consumption decreased13.02.01.0260.000730%Not Available
Stool analysis abnormal13.05.02.0040.000730%Not Available
Escherichia infection11.02.10.0040.000730%Not Available
Tricuspid valve disease02.07.05.0040.000730%
Purulence11.01.08.0600.001095%Not Available
Foaming at mouth17.02.05.056; 08.01.03.070; 07.05.05.0190.001095%Not Available
Vital functions abnormal13.15.01.0150.000730%Not Available
Nail bed inflammation23.02.05.0230.000730%Not Available
Cell marker increased13.22.01.0100.004379%Not Available
Rectal fissure07.03.01.0070.000730%
The 40th Page    First    Pre   40 41    Next   Last    Total 41 Pages