Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etoricoxib
Drug ID BADD_D00856
Description Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid. It is approved in more than 60 countries worldwide but not in the US.
Indications and Usage For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
Marketing Status Not Available
ATC Code M01AH05
DrugBank ID DB01628
KEGG ID D03710
MeSH ID D000077613
PubChem ID 123619
TTD Drug ID D09MGR
NDC Product Code 68554-0053; 46708-889; 42765-006
Synonyms Etoricoxib | MK 0663 | MK-0663 | MK0663 | Arcoxia | L-791456 | L 791456 | L791456
Chemical Information
Molecular Formula C18H15ClN2O2S
CAS Registry Number 202409-33-4
SMILES CC1=NC=C(C=C1)C2=C(C=C(C=N2)Cl)C3=CC=C(C=C3)S(=O)(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Bursitis15.04.01.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholecystitis09.03.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Corneal abrasion06.11.03.001; 12.01.04.001--Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Costochondritis15.07.03.001--Not Available
Cough22.02.03.001--
Cyst16.02.02.002; 08.03.05.001--Not Available
Cystitis20.03.02.002; 11.01.14.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diastolic hypertension24.08.02.006--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ear disorder04.03.01.001--Not Available
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