Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Etidronic acid
Drug ID BADD_D00849
Description Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid].[A203111] Etidronic acid was granted FDA approval on 1 September 1977.[L13901]
Indications and Usage For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
Marketing Status Prescription; Discontinued
ATC Code M05BA01
DrugBank ID DB01077
KEGG ID D02373
MeSH ID D012968
PubChem ID 3305
TTD Drug ID D00NNC
NDC Product Code Not Available
Synonyms Etidronic Acid | (1-hydroxyethylene)diphosphonic acid | Hydroxyethylidene Diphosphonic Acid | Diphosphonic Acid, Hydroxyethylidene | Etidronate | 1-Hydroxyethane-1,1-Diphosphonate | 1 Hydroxyethane 1,1 Diphosphonate | 1-Hydroxyethylidene-1,1-Bisphosphonate | 1 Hydroxyethylidene 1,1 Bisphosphonate | EHDP | 1,1-hydroxyethylenediphosphonate | 1,1 hydroxyethylenediphosphonate | HEDP | Hydroxyethanediphosphonate | Ethanehydroxyphosphate | Ethanehydroxydiphosphonate | Etidronate Disodium | Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt | Sodium Etidronate | Etidronate, Sodium | Disodium 1-Hydroxyethylene Diphosphonate | 1-Hydroxyethylene Diphosphonate, Disodium | Diphosphonate, Disodium 1-Hydroxyethylene | Disodium 1 Hydroxyethylene Diphosphonate | Disodium Etidronate | Etidronate, Disodium | HEDSPA | Dicalcium Etidronate | Etidronate, Dicalcium | Dicalcium EHDP | EHDP, Dicalcium | Xidifon | Xydiphone | Xidiphon | Didronel | Etidronate, Tetrapotassium Salt | Salt Etidronate, Tetrapotassium | Tetrapotassium Salt Etidronate | (1-hydroxyethylene)diphosphonic acid, Tetrapotassium Salt
Chemical Information
Molecular Formula C2H8O7P2
CAS Registry Number 2809-21-4
SMILES CC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Bone pain15.02.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dyspepsia07.01.02.001--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Fracture15.08.02.001; 12.04.02.001--
Gastritis07.08.02.001--
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.001--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypercalcaemia of malignancy05.08.02.001; 16.32.01.001; 14.04.01.009--Not Available
Hypersensitivity10.01.03.003--
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