Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethotoin
Drug ID BADD_D00847
Description Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread of seizure activity rather than to abolish the primary focus of seizure discharges. Ethotoin is no longer commonly used.
Indications and Usage For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures.
Marketing Status Prescription; Discontinued
ATC Code N03AB01
DrugBank ID DB00754
KEGG ID D00708
MeSH ID C084606
PubChem ID 3292
TTD Drug ID D05EPM
NDC Product Code 55292-602; 45562-1133
Synonyms ethotoin | Peganone
Chemical Information
Molecular Formula C11H12N2O2
CAS Registry Number 86-35-1
SMILES CCN1C(=O)C(NC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Body temperature increased13.15.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Gingival hypertrophy07.09.03.006--Not Available
Headache17.14.01.001--
Hypoaesthesia17.02.06.023--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lymphadenopathy01.09.01.002--Not Available
Lymphoma16.20.01.001; 01.12.01.001--Not Available
Nausea07.01.07.001--
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.001--Not Available
Nystagmus06.05.02.006; 17.02.02.006--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Sensory loss17.02.07.007--Not Available
Stevens-Johnson syndrome11.07.01.005; 10.01.03.020; 23.03.01.007; 12.03.01.014--
Systemic lupus erythematosus23.03.02.006; 15.06.02.003; 10.04.03.004--Not Available
Vomiting07.01.07.003--
Emotional distress19.04.02.008--Not Available
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