Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethinyl estradiol
Drug ID BADD_D00844
Description Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability.[A191107] These properties were achieved by the substitution of an ethinyl group at carbon 17 of [estradiol].[A191107] Ethinylestradiol soon replaced [mestranol] in contraceptive pills.[A191107] Ethinylestradiol was granted FDA approval on 25 June 1943.[L11884]
Indications and Usage For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Marketing Status Prescription; Discontinued
ATC Code G03CA01; L02AA03
DrugBank ID DB00977
KEGG ID D00554
MeSH ID D004997
PubChem ID 5991
TTD Drug ID D06NXY
NDC Product Code 65089-0044; 12860-0463; 60870-0463; 63190-0620; 44132-002; 51927-1856; 22552-0034; 44132-010
Synonyms Ethinyl Estradiol | Estradiol, Ethinyl | Ethynyl Estradiol | Estradiol, Ethynyl | Ethinyloestradiol | 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)- | Ethinyl Estradiol Hemihydrate | Hemihydrate, Ethinyl Estradiol | Ethinyl Estradiol, (8 alpha)-Isomer | Ethinyl Estradiol, (8 alpha,17 alpha)-Isomer | Ethinyl Estradiol, (8 alpha,9 beta,13 alpha,14 beta)-Isomer | Progynon C | Microfollin | Microfollin Forte | Ethinyl-Oestradiol Effik | Ethinyl Oestradiol Effik | Ethinylestradiol Jenapharm | Jenapharm, Ethinylestradiol | Lynoral | Estinyl | Ethinyl Estradiol, (9 beta,17 alpha)-Isomer
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 57-63-6
SMILES CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450Q14097Not AvailableNot Available
HepatotoxicityCytochrome P450 3A4P08684T37848Not Available
HepatotoxicityFibroblast growth factor 4P08620T28076Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Benign hepatic neoplasm16.06.01.001; 09.04.01.001--Not Available
Breast discharge21.05.05.001--Not Available
Breast enlargement21.05.04.001--Not Available
Breast tenderness21.05.05.004--Not Available
Budd-Chiari syndrome24.01.03.001; 09.01.06.001--
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cataract06.06.01.001--
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.006--Not Available
Cervical discharge21.06.01.001--Not Available
Uterine cervical erosion21.06.01.006--Not Available
Chloasma23.05.01.001; 18.08.02.002--Not Available
Colitis07.08.01.001--
Contact lens intolerance06.01.01.003--Not Available
Depression19.15.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Embolism arterial24.01.01.014--
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythema nodosum23.07.02.001; 10.02.01.020--Not Available
Gallbladder disorder09.03.02.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemolytic uraemic syndrome01.06.02.001; 20.01.03.011--
Headache17.14.01.001--
Hepatic adenoma16.06.01.002; 09.04.01.002--Not Available
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