Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethacrynic acid
Drug ID BADD_D00840
Description A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
Indications and Usage For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Marketing Status Prescription; Discontinued
ATC Code C03CC01
DrugBank ID DB00903
KEGG ID D00313
MeSH ID D004976
PubChem ID 3278
TTD Drug ID D06TNL
NDC Product Code 60429-887; 50228-334; 64380-909; 68180-159; 42413-0059; 76055-0022; 72134-003; 52817-367; 58032-2020; 58032-1015; 0832-1690; 48581-320; 0054-0415; 17337-0429; 65571-0016; 68682-011; 49884-276; 25010-215; 42799-405; 65841-175; 17337-0401; 42973-169; 69238-1126
Synonyms Ethacrynic Acid | Acid, Ethacrynic | Etacrynic Acid | Acid, Etacrynic | Ethacrinic Acid | Acid, Ethacrinic | Hydromedin | Edecrin | Ethacrynate Sodium | Sodium, Ethacrynate | Ethacrynic Acid, Sodium Salt
Chemical Information
Molecular Formula C13H12Cl2O4
CAS Registry Number 58-54-8
SMILES CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Anxiety19.06.02.002--
Application site irritation08.02.01.003; 12.07.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Asthenia08.01.01.001--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Deafness04.02.01.001--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dysphagia07.01.06.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperuricaemia14.09.01.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Liver function test abnormal13.03.01.013--Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
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