Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estropipate
Drug ID BADD_D00836
Description Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in men and postmenopausal women), treatment of prostate cancer and prevention of osteoporosis.
Indications and Usage Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and prevent postmenopausal osteoporosis.
Marketing Status Prescription; Discontinued
ATC Code G03CA07; G03CC04
DrugBank ID DB04574
KEGG ID D00948
MeSH ID C009927
PubChem ID 5284555
TTD Drug ID D03IUY
NDC Product Code 64918-0106; 12875-9998
Synonyms estropipate | piperazine estrone sulfate | estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1) | Ogen | Harmogen | Genoral | Harmonet | Ortho-Est
Chemical Information
Molecular Formula C22H32N2O5S
CAS Registry Number 7280-37-7
SMILES CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Tenderness08.01.08.005--Not Available
Tension19.06.02.005--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thrombophlebitis superficial24.01.02.002--
Thrombosis24.01.01.006--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Uterine leiomyoma21.07.02.004; 16.04.02.001--Not Available
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Vaginal inflammation21.14.02.001--
Varicose vein24.10.04.001--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Vulvovaginal candidiasis21.14.02.003; 11.03.03.005--Not Available
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Withdrawal bleed21.01.01.010; 08.06.02.005--Not Available
Breast discomfort21.05.05.007--Not Available
Deep vein thrombosis24.01.02.003--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Embolism24.01.01.009--
Inflammation08.01.05.007--Not Available
Porphyrin metabolism disorder14.14.01.006; 09.01.10.004; 03.08.01.006--Not Available
Corneal disorder06.08.01.004--Not Available
Retinal vascular thrombosis24.01.07.001; 06.10.01.004--Not Available
Cystitis noninfective20.03.02.001--
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