Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estramustine phosphate sodium
Drug ID BADD_D00828
Description A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Indications and Usage For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Marketing Status Prescription
ATC Code L01XX11
DrugBank ID DB01196
KEGG ID D02398
MeSH ID D004961
PubChem ID 444000
TTD Drug ID D03SRY
NDC Product Code 0013-0132
Synonyms Estramustine | Estracyt | Estramustine Phosphate Sodium | Phosphate Sodium, Estramustine | Leo-275 | Leo 275 | Leo275 | NSC-89199 | NSC 89199 | NSC89199 | Emcyt | Estramustinphosphate | Estramustin Phosphate | Phosphate, Estramustin
Chemical Information
Molecular Formula C23H30Cl2NNa2O6P
CAS Registry Number 52205-73-9
SMILES CC12CCC3C(C1CCC2OP(=O)([O-])[O-])CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl.[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Menopausal symptoms21.02.02.002--Not Available
Mood swings19.04.03.001--Not Available
Muscle spasms15.05.03.004--
Myocardial infarction02.02.02.007; 24.04.04.009--
Nausea07.01.07.001--
Night sweats23.02.03.006; 08.01.03.031--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pruritus23.03.12.001--
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Rash23.03.13.001--Not Available
Respiratory disorder22.02.07.002--Not Available
Skin exfoliation23.03.07.003--Not Available
Tenderness08.01.08.005--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat irritation22.02.05.013; 07.05.03.004--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Vomiting07.01.07.003--
Contusion23.03.11.002; 15.03.01.008; 12.01.06.001; 24.07.06.001--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Affect lability19.04.01.001--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Decreased appetite08.01.09.028; 14.03.01.005--
Pigmentation disorder23.05.03.001--Not Available
Gastrointestinal tract irritation07.08.03.008--Not Available
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