Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estramustine phosphate
Drug ID BADD_D00827
Description A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Indications and Usage For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Marketing Status Prescription
ATC Code L01XX11
DrugBank ID DB14674
KEGG ID D02398
MeSH ID D004961
PubChem ID 259329
TTD Drug ID D03SRY
NDC Product Code Not Available
Synonyms Estramustine | Estracyt | Estramustine Phosphate Sodium | Phosphate Sodium, Estramustine | Leo-275 | Leo 275 | Leo275 | NSC-89199 | NSC 89199 | NSC89199 | Emcyt | Estramustinphosphate | Estramustin Phosphate | Phosphate, Estramustin
Chemical Information
Molecular Formula C23H32Cl2NO6P
CAS Registry Number 4891-15-0
SMILES CC12CCC3C(C1CCC2OP(=O)(O)O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Embolism venous24.01.01.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gynaecomastia05.05.02.003; 21.05.04.003--
Headache17.14.01.001--
Hypertension24.08.02.001--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Libido decreased19.08.03.001; 21.03.02.005--
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Polyuria20.02.03.002--Not Available
Rash23.03.13.001--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Transaminases increased13.03.01.015--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Embolism24.01.01.009--
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