Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Estazolam
Drug ID BADD_D00819
Description A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Indications and Usage For the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings.
Marketing Status Prescription; Discontinued
ATC Code N05CD04
DrugBank ID DB01215
KEGG ID D00311
MeSH ID D004949
PubChem ID 3261
TTD Drug ID D0P2CK
NDC Product Code 0591-0744; 51862-074; 12828-0077; 51862-069; 0591-0745; 70954-480; 70954-481; 51862-073; 51862-070; 48087-0031
Synonyms Estazolam | Tasedan | ProSom | D-40TA | D40TA | Nuctalon
Chemical Information
Molecular Formula C16H11ClN4
CAS Registry Number 29975-16-4
SMILES C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ear pain04.03.01.003--
Electroencephalogram abnormal13.07.03.001--Not Available
Enterocolitis07.08.03.003--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Euphoric mood19.04.02.006--
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Flat affect19.04.01.004--Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastritis07.08.02.001--
Gastrointestinal pain07.01.05.005--
Haematuria20.02.01.006; 24.07.01.047--
Hallucination19.10.02.002--
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Hostility19.05.01.003--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hypokinesia17.01.02.009--Not Available
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