Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Esmolol hydrochloride
Drug ID BADD_D00814
Description Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses. It works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.
Indications and Usage For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention.
Marketing Status Prescription; Discontinued
ATC Code C07AB09
DrugBank ID DB00187
KEGG ID D00644
MeSH ID C036604
PubChem ID 104769
TTD Drug ID D03XTC
NDC Product Code 10019-120; 71872-7049; 0404-9858; 63660-0004; 55150-194; 68083-211; 44567-812; 51662-1371; 10019-670; 63323-652; 25021-308; 14501-0075; 25021-314; 51662-1427; 50090-4699; 62009-1905; 51662-1322; 51662-1444; 11712-260; 10019-075; 10019-115; 50090-4512; 71872-7136; 10019-672; 25021-309; 10019-055; 44567-811; 0404-9825; 67457-182; 52584-194; 10019-666; 10019-668
Synonyms esmolol | Brevibloc | esmolol hydrochloride | ASL 8052 | ASL-8052
Chemical Information
Molecular Formula C16H26ClNO4
CAS Registry Number 81161-17-3
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depression19.15.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Ovulation pain21.11.02.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Paraesthesia17.02.06.005--
Peripheral ischaemia24.04.03.002--
Pulmonary oedema22.01.03.003; 02.05.02.003--
The 1th Page    1 2    Next   Last    Total 2 Pages