Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol sodium
Drug ID BADD_D00789
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D01337
MeSH ID D011464
PubChem ID 6364626
TTD Drug ID D0V0IX
NDC Product Code 68245-0005; 54893-0004; 62756-033; 0173-0519; 82231-106; 0009-5164; 14474-025; 61556-030; 0703-1985; 0173-0517; 45542-1157; 0703-1995
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H31NaO5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)[O-])O2)O)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.012--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Back pain15.03.04.005--
Bradycardia02.03.02.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Eczema23.03.04.006--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hyperaesthesia17.02.06.004--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersplenism01.09.02.002--Not Available
Hyperthyroidism14.11.01.011; 05.02.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Influenza22.07.02.001; 11.05.03.001--Not Available
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervousness19.06.02.003--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
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