Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Joint swelling15.01.02.0040.000927%Not Available
Kidney infection20.01.09.004; 11.01.14.0060.000556%
Laceration23.03.11.004; 12.01.06.0060.000742%Not Available
Lacrimation increased06.08.02.0040.000371%
Left ventricular failure02.05.02.0010.000097%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Liver disorder09.01.08.0010.000927%Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.0130.000927%Not Available
Localised infection11.01.08.0060.001298%Not Available
Loss of consciousness17.02.04.0040.003339%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.000556%Not Available
Lung disorder22.02.07.0010.001855%Not Available
Lung infiltration22.01.02.0040.000371%Not Available
Lymphadenopathy01.09.01.0020.000927%Not Available
Malaise08.01.01.0030.011315%
Mass08.03.05.0030.000371%Not Available
Melaena24.07.02.013; 07.12.02.0040.000556%Not Available
Memory impairment19.20.01.003; 17.03.02.0030.001298%
Migraine24.03.05.003; 17.14.02.0010.000927%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.002411%
Myalgia15.05.02.0010.002040%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.0010.001298%
Nasopharyngitis11.01.13.002; 22.07.03.0020.005008%Not Available
Nausea07.01.07.0010.025599%
Neck pain15.03.04.0090.001669%
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