Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.012428%
Fungal infection11.03.05.001--Not Available
Gait disturbance08.01.02.002; 17.02.05.016--
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.0030.000371%Not Available
Gastric cancer16.13.03.001; 07.21.02.0010.000097%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000556%
Gastritis07.08.02.001--
Gastroenteritis11.01.07.004; 07.19.03.0010.000371%Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.0050.000556%Not Available
Gastrointestinal disorder07.11.01.0010.001298%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.002782%Not Available
Gastrointestinal infection07.19.02.005; 11.01.07.0120.000371%Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.0040.000556%
Goitre14.11.01.008; 05.02.01.0010.001855%Not Available
Gout15.01.06.001; 14.09.01.0010.000556%Not Available
Haematemesis07.12.02.002; 24.07.02.0110.001298%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000556%Not Available
Haematoma24.07.01.0010.001113%
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.0020.000556%Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.002040%Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.003339%Not Available
Haemothorax24.07.01.008; 22.05.02.001; 12.01.03.002--
Headache17.14.01.0010.026526%
Heart rate abnormal13.14.04.0060.000371%Not Available
Heart rate increased13.14.04.0020.003895%Not Available
Heart rate irregular13.14.04.0030.000371%Not Available
Hepatic cirrhosis09.01.04.0010.000194%Not Available
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