Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.0040.001045%Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.000181%
Haemothorax12.01.18.005; 24.07.01.008; 22.05.02.001--
Headache17.14.01.0010.011621%
Hepatic cirrhosis09.01.04.0010.000206%Not Available
Hepatic failure09.01.03.0020.000123%
Hepatic fibrosis24.08.06.002; 09.01.04.0020.000082%Not Available
Hepatomegaly09.01.05.0010.000082%Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000082%Not Available
Hyperaesthesia17.02.06.004; 23.03.03.0800.000082%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.000082%
Hyperhidrosis23.02.03.004; 08.01.03.0280.000592%
Hyperkalaemia14.05.03.001--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.0030.000732%
Hypersomnia19.02.05.001; 17.15.01.0010.000181%
Hypersplenism01.09.02.0020.000304%Not Available
Hyperthyroidism14.11.01.011; 05.02.02.0010.000617%
Hypervolaemia02.05.04.019; 14.05.06.0030.001439%Not Available
Hypoaesthesia17.02.06.023; 23.03.03.081--Not Available
Hypotension24.06.03.0020.003430%
Hypovolaemic shock24.06.02.0170.000082%Not Available
Hypoxia22.02.02.0030.001563%
Immune system disorder10.02.01.0010.000181%Not Available
Impaired healing08.03.02.0010.000082%Not Available
Incoherent19.10.03.006; 17.02.08.0020.000123%Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
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