| Drug Name |
Eplerenone |
| Drug ID |
BADD_D00786 |
| Description |
Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors. |
| Indications and Usage |
For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction. |
| Marketing Status |
approved |
| ATC Code |
C03DA04 |
| DrugBank ID |
DB00700
|
| KEGG ID |
D01115
|
| MeSH ID |
D000077545
|
| PubChem ID |
443872
|
| TTD Drug ID |
D0Q4SD
|
| NDC Product Code |
16637-0060; 63629-9414; 69367-307; 31722-050; 42291-455; 71205-864; 70966-0033; 71216-3010; 42291-454; 59762-1720; 70436-098; 71205-863; 60687-451; 73309-095; 16729-293; 0185-5369; 51991-878; 0025-1710; 0025-1720; 69367-308; 14501-0007; 31722-049; 16812-001; 46014-1102; 73320-004; 68554-0116; 59762-1710; 66993-343; 70436-099; 0009-5276; 16729-294; 51991-877; 66993-344; 73320-005; 0185-5368 |
| UNII |
6995V82D0B
|
| Synonyms |
Eplerenone | Eplerenon | Inspra | 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone |
