Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin hydrochloride
Drug ID BADD_D00785
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D02214
MeSH ID D015251
PubChem ID 65348
TTD Drug ID D0C9XJ
NDC Product Code 77391-002; 0009-5093; 0143-9202; 0009-5091; 59923-701; 0143-9203; 27831-002
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11.ClH
CAS Registry Number 25316-40-9
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O .Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukaemia16.01.03.001; 01.10.03.001--
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.003--
Metastases to liver16.22.02.001; 09.04.02.004--Not Available
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
Mucous membrane disorder08.01.06.004--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.001--
Nail disorder23.02.05.002--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuralgia17.02.07.005--
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Opportunistic infection11.01.08.007--Not Available
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Oral pain07.05.03.002--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Ovarian cancer21.11.01.003; 16.12.04.001--Not Available
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