Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin
Drug ID BADD_D00784
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status approved
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D07901
MeSH ID D015251
PubChem ID 41867
TTD Drug ID D0C9XJ
NDC Product Code Not Available
UNII 3Z8479ZZ5X
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11
CAS Registry Number 56420-45-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cellulitis11.02.01.001; 23.11.02.004--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000414%Not Available
Chills15.05.03.016; 08.01.09.0010.000224%
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.0010.000112%
Cyst16.02.02.002; 08.03.05.001--Not Available
Cystitis haemorrhagic20.03.02.0030.000112%Not Available
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000246%
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.000112%
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram QRS complex abnormal13.14.05.016--Not Available
Electrocardiogram ST segment depression13.14.05.005--Not Available
Embolism arterial24.01.01.014--
Embolism venous24.01.01.003--Not Available
Erythema23.03.06.0010.000280%Not Available
Extravasation08.01.03.008--Not Available
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.001007%
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastric cancer16.13.03.001; 07.21.02.0010.000437%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene