Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin
Drug ID BADD_D00784
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D07901
MeSH ID D015251
PubChem ID 41867
TTD Drug ID D0C9XJ
NDC Product Code Not Available
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11
CAS Registry Number 56420-45-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000533%
Abdominal pain upper07.01.05.0030.001066%
Acute lymphocytic leukaemia16.01.01.001; 01.10.01.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.0010.001332%
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.0010.000533%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anuria20.01.03.002--Not Available
Aphthous ulcer07.05.06.0020.000533%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Asthenia08.01.01.0010.000799%Not Available
Atrioventricular block02.03.01.002--Not Available
Azoospermia21.03.03.001--
Bacteraemia11.01.11.0010.000533%
Bladder stenosis20.03.01.011--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure increased13.14.03.0050.000533%Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.0010.000533%Not Available
Bundle branch block02.03.01.009--Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cardiac failure02.05.01.0010.000208%
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
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