Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ephedrine
Drug ID BADD_D00777
Description Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine].[A193698] Ephedrine is an adrenergic receptor agonist used for its vasoconstrictive, positive chronotropic, and positive inotropic effects.[L12972] Ephedrine and [phenylephrine] are still commonly used to treat hypotension but their use in other indications has decreased due to the development of more selective adrenergic agonists.[A193701,A193704,L12975] Ephedrine was granted a type 7 FDA Approval on 29 April 2016.[L12975]
Indications and Usage Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
Marketing Status Prescription
ATC Code C01CA26; R01AA03; R01AB05; R03CA02; S01FB02
DrugBank ID DB01364
KEGG ID D00124
MeSH ID D004809
PubChem ID 9294
TTD Drug ID D0LG8E
NDC Product Code 57218-151
Synonyms Ephedrine | Erythro Isomer of Ephedrine | Ephedrine Erythro Isomer | Sal-Phedrine | Sal Phedrine | SalPhedrine | Ephedrine Sulfate | Sulfate, Ephedrine | Ephedrine Hydrochloride | Hydrochloride, Ephedrine | Ephedrine Renaudin | Renaudin, Ephedrine
Chemical Information
Molecular Formula C10H15NO
CAS Registry Number 299-42-3
SMILES CC(C(C1=CC=CC=C1)O)NC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Benign prostatic hyperplasia21.04.02.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Delirium19.13.02.001--
Dependence19.07.02.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Euphoric mood19.04.02.006--
Extrasystoles02.03.02.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Muscle spasms15.05.03.004--
Nasal dryness22.04.03.002--Not Available
Nausea07.01.07.001--
The 1th Page    1 2    Next   Last    Total 2 Pages