Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Enzalutamide
Drug ID BADD_D00775
Description Enzalutamide is an androgen receptor inhibitor for the treatment of castration-resistant prostate cancer. FDA approved on August 31, 2012.
Indications and Usage Enzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
Marketing Status Prescription
ATC Code L02BB04
DrugBank ID DB08899
KEGG ID D10218
MeSH ID C540278
PubChem ID 15951529
TTD Drug ID D0QK5X
NDC Product Code 54893-0044; 55111-976; 0469-0625; 65392-2209; 68554-0106; 65015-876; 62128-0388; 65129-1376; 59285-018; 42385-733; 0469-0725; 11014-0003; 15308-1121; 0469-0125
Synonyms enzalutamide | 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-benzamide | enzalutamide D3 | HC-1119 | HC 1119 | 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-(methyl-d3)benzamide | Xtandi | MDV 3100 | MDV3100 | MDV-3100
Chemical Information
Molecular Formula C21H16F4N4O2S
CAS Registry Number 915087-33-1
SMILES CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Embolic stroke24.01.04.010; 17.08.01.032--Not Available
Emotional disorder19.04.02.005--Not Available
Emotional poverty19.04.02.0150.001471%Not Available
Encephalopathy17.13.02.001--
Endocarditis11.01.16.001; 02.09.01.0010.000384%
Epilepsy17.12.03.0020.011032%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.001471%
Erysipelas23.09.01.002; 11.02.06.0010.002206%Not Available
Erythema23.03.06.001--Not Available
Escherichia sepsis11.02.10.0020.001471%Not Available
Exophthalmos06.09.04.001; 05.02.02.0020.002206%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001--Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Facial paralysis17.04.03.0080.003677%Not Available
Faeces discoloured07.01.03.002--Not Available
Faeces hard07.01.03.0030.002942%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.001151%Not Available
Fall12.01.08.002--
Fatigue08.01.01.0020.532495%
Fear19.06.03.001--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.0140.038981%Not Available
Feeling cold08.01.09.0080.006619%Not Available
Feeling hot08.01.09.009--Not Available
Feeling jittery08.01.09.0160.004413%Not Available
Femoral neck fracture15.08.03.002; 12.04.01.002--Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
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