Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Enoxaparin sodium
Drug ID BADD_D00772
Description Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies.[L31393] Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Indications and Usage For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Marketing Status Prescription; Discontinued
ATC Code B01AB05
DrugBank ID DB01225
KEGG ID D03674
MeSH ID C000711671
PubChem ID 60196282
TTD Drug ID D01ZJK
NDC Product Code 63323-539; 63323-586; 50090-3445; 11797-761; 0075-8030; 0075-8014; 63323-568; 60505-0795; 70710-1760; 60505-0793; 55154-6689; 55154-6690; 68001-458; 0548-5602; 0703-8530; 63323-537; 0548-5606; 11797-759; 70398-0003; 0781-3224; 0955-1003; 0955-1015; 68001-463; 60505-0794; 55154-3544; 63323-564; 63323-566; 28955-002; 63323-607; 63323-605; 55154-3542; 0781-3238; 63323-531; 0955-1010; 55154-3541; 63323-655; 0548-5603; 0075-0621; 0781-3299; 16714-036; 0548-5635; 0548-5608; 63323-559; 16714-016; 0075-8013; 0781-3655; 16714-046; 68001-464; 0703-8560; 68001-461; 0548-5631; 60505-0796; 0781-3133; 11797-757; 55154-6691; 63323-535; 0548-5605; 0955-1008; 0955-1006; 0548-5601; 0703-8540; 70710-1759; 0075-0620; 0703-8510; 0548-5607; 0548-5637; 63323-584; 0075-0622; 11797-763; 0075-8018; 0075-0626; 16714-026; 0075-8016; 63323-609; 76420-086; 16714-066; 0703-8580; 0781-3356; 55154-3540; 71288-410; 60505-0792; 0075-8022; 0548-5604; 55154-4028; 0781-3298; 62255-1325; 0781-3500; 0955-1004; 68001-457; 68001-462; 0075-8025; 0075-0623; 0781-3256; 11797-758; 70710-1761; 16714-056; 55154-6692; 19657-0003; 0548-5632; 0703-8680; 11797-762; 71288-411; 60505-0798; 0075-0624; 0955-1016; 0075-2915; 60505-0791; 63323-533; 0781-3268; 68001-460; 70710-1763; 11797-760; 70710-1758; 0548-5633; 0075-8020; 0781-3262; 55154-9576; 70710-1757; 63323-589; 68001-459; 0955-1012; 0548-5636; 70710-1762; 0075-2912; 55154-3543; 0781-3246; 0781-3612; 55154-6688; 0703-8610; 16714-006; 0548-5634; 19657-0001; 0781-3428
Synonyms enoxaparin sodium | RP 54563
Chemical Information
Molecular Formula C42H59N3Na4O35S2
CAS Registry Number 679809-58-6
SMILES CC1C(C(OC(C1OC2CC(C(C(C2O)O)OC3C(C(C(C(O3)COS(=O)(=O)O)OC4C(C(C=C(O4)C(=O)[O-])O )O)O)NC(=O)C)C(=O)[O-])CO)OC5C(C(C(OC5C(=O)[O-])OC6C7COC(O7)C(C6O)NS(=O)(=O)[O-] )O)O)NC(=O)C.[Na+].[Na+].[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Atrial fibrillation02.03.03.002--
Cardiac failure02.05.01.001--
Confusional state19.13.01.001; 17.02.03.005--
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.003--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Epidural anaesthesia25.01.03.004--Not Available
Erythema23.03.06.001--Not Available
Extradural haematoma12.01.10.002; 24.07.04.002; 17.08.05.001--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Injection site haemorrhage08.02.03.005; 24.07.01.010; 12.07.03.005--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.004--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
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