Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Encainide hydrochloride
Drug ID BADD_D00769
Description All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Indications and Usage Encainide is a class Ic antiarrhythmic agent which was used for management of irregular heartbeats, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
Marketing Status Not Available
ATC Code C01BC08
DrugBank ID DB01228
KEGG ID D03991
MeSH ID D016700
PubChem ID 48040
TTD Drug ID D06PAZ
NDC Product Code Not Available
Synonyms Encainide | Encainide, (+)-Isomer | Enkaid | MJ-9067 | MJ 9067 | MJ9067 | Encainide Hydrochloride | Encainide Hydrochloride, (+-)-Isomer | Encainide, (-)-Isomer
Chemical Information
Molecular Formula C22H29ClN2O2
CAS Registry Number 66794-74-9
SMILES CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrioventricular block02.03.01.002--Not Available
Blood insulin increased13.10.02.001--Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Electrocardiogram QRS complex prolonged13.14.05.003--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
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