ADReCS

Pharmaceutical Information

Drug Name	Enalaprilat
Drug ID	BADD_D00768
Description	Enalaprilat is the active metabolite of the orally available pro-drug, [enalapril]. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of the kidney, down-regulation of this protein results in reduced blood pressure and blood fluid volume. Enalaprilat was originally created to overcome the limitations of the first ACE inhibitor, captopril, which had numerous side effects and left a metallic taste in the mouth. Removal of the problematic thiol group from captopril resulted in enalaprilat, which was then modified further with an ester to create the orally available pro-drug enalapril. Enalaprilat is poorly orally available and is therefore only available as an intravenous injection for the treatment of hypertension when oral therapy is not possible.
Indications and Usage	Enalaprilat injection is indicated for the treatment of hypertension when oral therapy is not practical.
Marketing Status	approved
ATC Code	Not Available
DrugBank ID	DB09477
KEGG ID	D03769
MeSH ID	D015773
PubChem ID	5462501
TTD Drug ID	D0N5HJ
NDC Product Code	51662-1477; 0143-9786; 43598-078; 71796-040; 43598-169; 0143-9787
UNII	Q508Q118JM
Synonyms	Enalaprilat \| Enalaprilic Acid \| Enalaprilat Dihydrate \| Enalaprilat Citrate, Anhydrous \| Enalaprilat, (R)-Isomer, Anhydrous \| Pres iv \| Vasotec \| Enalaprilat Anhydrous \| Xanef \| 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate \| MK-422 \| MK 422 \| MK422

Chemical Information

Molecular Formula	C18H24N2O5
CAS Registry Number	76420-72-9
SMILES	CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Toxic epidermal necrolysis	23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006	-	-
Transient ischaemic attack	24.04.06.005; 17.08.04.001	0.006079%
Upper gastrointestinal haemorrhage	24.07.02.024; 07.12.02.006	0.005065%
Upper respiratory tract infection	11.01.13.009; 22.07.03.011	-	-
Urinary retention	20.02.02.011	0.002026%
Urinary tract disorder	20.08.01.001	0.002026%		Not Available
Urinary tract infection	20.08.02.001; 11.01.14.004	-	-
Urticaria	23.04.02.001; 10.01.06.001	0.022491%
Vascular purpura	01.01.04.007; 24.07.06.011; 23.06.01.008	0.002026%		Not Available
Vasculitis	24.12.04.027; 10.02.02.006	-	-
Ventricular extrasystoles	02.03.04.007	0.003039%		Not Available
Ventricular tachycardia	02.03.04.010	0.002026%
Vertigo	17.02.12.002; 04.04.01.003	0.007092%
Vision blurred	06.02.06.007; 17.17.01.010	-	-
Vomiting	07.01.07.003	0.025327%
Mental status changes	19.07.01.001	0.006079%		Not Available
Tubulointerstitial nephritis	20.05.02.002	0.003039%		Not Available
Intracardiac thrombus	02.11.01.017; 24.01.05.003	0.002026%		Not Available
Ischaemic cardiomyopathy	02.04.01.004; 24.04.04.019	0.004052%		Not Available
Brain oedema	12.01.10.010; 17.07.02.003	0.002026%
Red blood cell sedimentation rate increased	13.01.03.001	-	-	Not Available
Nocturnal dyspnoea	22.02.01.019; 02.11.05.009	0.002026%		Not Available
Precancerous skin lesion	23.01.06.004	0.002026%		Not Available
General physical health deterioration	08.01.03.018	0.006079%		Not Available
Tachyarrhythmia	02.03.02.008	0.002026%		Not Available
Idiosyncratic drug reaction	08.06.01.002	0.003039%		Not Available
Dysstasia	08.01.03.089; 17.02.02.012; 15.03.05.011	0.002026%		Not Available
Intervertebral disc protrusion	15.10.01.004	0.002026%		Not Available
Blood pressure inadequately controlled	24.06.01.007	0.005471%		Not Available
Acute coronary syndrome	24.04.04.011; 02.02.02.015	-	-	Not Available

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