Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Swelling08.01.03.015--Not Available
Swelling face23.04.01.018; 10.01.05.018--Not Available
Tachycardia02.03.02.007--Not Available
Throat irritation22.02.05.013; 07.05.03.0040.001089%Not Available
Thrombocytopenia01.08.01.0020.009802%Not Available
Thrombocytosis01.08.02.0010.002178%Not Available
Thrombophlebitis superficial24.01.02.0020.001634%
Thrombosis24.01.01.0060.021237%Not Available
Tooth loss07.09.09.0010.001089%Not Available
Toothache07.09.06.0010.001634%
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Tremor17.01.06.002--
Trichorrhexis23.02.06.0070.001089%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.0090.002723%
Urinary tract infection20.08.02.001; 11.01.14.0040.007079%
Urticaria23.04.02.001; 10.01.06.001--
Viral infection11.05.04.0010.002178%Not Available
Vision blurred06.02.06.007; 17.17.01.0100.005445%
Visual impairment06.02.06.0080.005445%Not Available
Vitreous floaters06.09.01.0050.001089%
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
White blood cell count decreased13.01.06.012--
White blood cell count increased13.01.06.013--Not Available
Mental status changes19.07.01.001--Not Available
Hypoacusis04.02.01.0060.006534%
Peripheral swelling08.01.03.053; 02.05.04.0150.012524%Not Available
Abasia17.02.05.035; 08.01.02.007--Not Available
Balance disorder17.02.02.007--Not Available
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