Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature delivery18.07.01.006--
Pruritus23.03.12.0010.019059%
Pulmonary embolism22.06.02.001; 24.01.06.0010.008168%Not Available
Purpura23.06.01.004; 01.01.04.003; 24.07.06.0050.001089%
Pyrexia08.05.02.003--
Rash23.03.13.0010.034851%Not Available
Rash erythematous23.03.06.003--Not Available
Rash generalised23.03.13.0020.002723%Not Available
Rash maculo-papular23.03.13.004--
Rash pruritic23.03.12.002--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Red blood cell count decreased13.01.05.0070.001634%Not Available
Renal disorder20.01.02.002--Not Available
Renal failure20.01.03.005--Not Available
Renal vein thrombosis24.01.11.002; 20.01.07.0110.001089%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Rhinorrhoea22.02.05.0100.003267%
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin discolouration23.03.03.0050.003267%Not Available
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.003--Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Splenomegaly01.09.02.0010.001634%Not Available
Stomatitis07.05.06.005--
Stress19.06.02.0040.001634%Not Available
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