Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.008168%Not Available
Abdominal distension07.01.04.0010.004901%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acne23.02.01.0010.001634%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000994%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Alanine aminotransferase increased13.03.01.0030.003267%
Alopecia23.02.02.0010.024504%
Ammonia increased13.03.01.0230.001089%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anger19.04.02.0010.002178%Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.0020.000994%Not Available
Arterial thrombosis24.01.01.0020.001089%Not Available
Arthralgia15.01.02.0010.019603%
Aspartate aminotransferase increased13.03.01.0060.002723%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.0010.001634%Not Available
Blood bilirubin increased13.03.01.0080.003812%
Blood bilirubin unconjugated increased13.03.01.0240.001634%Not Available
Blood creatinine increased13.13.01.0040.003267%
Blood glucose increased13.02.02.0020.002723%Not Available
Blood potassium decreased13.11.01.0100.001089%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood triglycerides increased13.12.03.0010.001089%Not Available
Body temperature increased13.15.01.001--Not Available
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