Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dyphylline
Drug ID BADD_D00737
Description Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Indications and Usage For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.
Marketing Status Discontinued
ATC Code R03DA01
DrugBank ID DB00651
KEGG ID D00691
MeSH ID D004400
PubChem ID 3182
TTD Drug ID D02PWM
NDC Product Code Not Available
Synonyms Dyphylline | Diphylline | Dihydroxypropyltheophylline | Diprophylline | Lufyllin | Dilin | Neothylline | Dylix
Chemical Information
Molecular Formula C10H14N4O4
CAS Registry Number 479-18-5
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Agitation19.06.02.001; 17.02.05.012--
Albuminuria20.02.01.001--Not Available
Circulatory collapse24.06.02.001--Not Available
Diarrhoea07.02.01.001--
Extrasystoles02.03.02.003--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Generalised tonic-clonic seizure17.12.01.002--Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Muscle twitching15.05.03.005--Not Available
Nausea07.01.07.001--
Palpitations02.01.02.003--
Polyuria20.02.03.002--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.014--Not Available
Ventricular arrhythmia02.03.04.006--
Vomiting07.01.07.003--
Inappropriate antidiuretic hormone secretion05.03.03.001; 14.05.07.001--Not Available
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