Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Droperidol
Drug ID BADD_D00731
Description A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Indications and Usage Droperidol is ssed to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
Marketing Status Prescription; Discontinued
ATC Code N05AD08
DrugBank ID DB00450
KEGG ID D00308
MeSH ID D004329
PubChem ID 3168
TTD Drug ID D03CJL
NDC Product Code 73309-288; 38779-0501; 64189-0601; 0517-9702
Synonyms Droperidol | Inapsine | Dehidrobenzperidol | Dehydrobenzperidol | Droleptan
Chemical Information
Molecular Formula C22H22FN3O2
CAS Registry Number 548-73-2
SMILES C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Akathisia19.06.02.006; 17.01.02.002--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Delayed recovery from anaesthesia17.02.04.011; 12.02.12.003--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dysphoria19.04.02.004--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Extrapyramidal disorder17.01.02.007--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Hallucination19.10.02.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperprolactinaemia05.03.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Hypovolaemia14.05.05.002--Not Available
Laryngospasm22.04.02.002--
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