Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxycycline
Drug ID BADD_D00725
Description Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
Indications and Usage Not Available
Marketing Status Prescription; Discontinued
ATC Code A01AB22; J01AA02
DrugBank ID DB00254
KEGG ID D00307
MeSH ID D004318
PubChem ID 54671203
TTD Drug ID D0S0LZ
NDC Product Code 63629-8212; 71205-616; 65841-823; 23155-133; 70934-085; 65841-822; 43063-985; 72789-199; 27808-233; 70934-178; 71335-0823; 50090-4833; 43063-886; 68180-657; 0713-0554; 40032-790; 67296-1368; 42291-156; 0713-0572; 55700-122; 43386-790; 68382-706; 50909-8106; 60219-1100; 67457-437; 0527-1535; 46708-249; 68180-651; 0527-1335; 70710-1124; 68084-743; 0299-3822; 55018-164; 53002-0673; 70710-1123; 67296-1385; 70771-1006; 0527-1338; 63304-615; 71610-220; 11014-0092; 49884-726; 50268-281; 61919-474; 70771-1008; 70518-0213; 68999-417; 40032-792; 70934-808; 50090-4592; 60687-344; 70710-1122; 0713-0571; 63304-130; 46708-250; 51407-387; 49884-727; 63187-672; 43386-791; 68180-652; 68382-782; 63629-2183; 0713-0570; 70518-3365; 69097-228; 63304-616; 68382-707; 63629-7751; 72189-006; 62135-417; 62332-249; 50090-1787; 63323-130; 67296-1762; 70771-1007; 67296-1025; 70710-1121; 63304-614; 70934-325; 52584-437; 63304-132; 0713-0555; 0404-9855; 62332-250; 66993-815; 23155-136; 43386-792; 65841-821; 55488-0200; 63187-936; 23155-135; 69238-1100; 49884-305; 0069-0970; 47621-017; 67296-1570; 68382-911; 50268-280; 71335-1988; 50090-3809; 50090-4599; 68071-2617; 72789-047; 67296-1688; 71335-1479; 40032-791; 63187-712; 71205-135; 63187-135; 69238-1500; 63304-173; 70771-1121; 68382-910; 0527-1537; 71335-0436; 50090-1472; 61919-433; 68071-4354; 69988-0020; 70771-1122; 71335-0861; 54348-573; 67296-1674; 0115-1327; 53002-0671; 61919-276; 55700-723; 53002-0672; 59929-631; 63629-7970; 70518-0187; 23155-134; 69238-1501; 70771-1009; 71205-385; 63304-131; 0143-9381; 68180-650; 70934-499
Synonyms Doxycycline | Doxycycline Monohydrate | Vibramycin | Atridox | Doxycycline Phosphate (1:1) | BMY-28689 | BMY 28689 | BMY28689 | BU-3839T | BU 3839T | BU3839T | Doryx | Doxycycline Calcium Salt (1:2) | Doxycycline Hyclate | Doxycycline Hemiethanolate | Doxycycline Monohydrochloride, 6-epimer | Doxycycline Monohydrochloride, 6 epimer | Doxycycline Monohydrochloride, Dihydrate | Doxycycline Calcium | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- | Alpha-6-Deoxyoxytetracycline | Alpha 6 Deoxyoxytetracycline | Doxycycline-Chinoin | Doxycycline Chinoin | Hydramycin | Oracea | Periostat | Vibra-Tabs | Vibra Tabs | Vibramycin Novum | Vibravenos
Chemical Information
Molecular Formula C22H24N2O8
CAS Registry Number 564-25-0
SMILES CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Gingival pain07.09.04.001--
Gingivitis11.01.04.013; 07.09.03.003--
Glossitis07.14.01.001--Not Available
Haemoglobin decreased13.01.05.0030.000105%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Headache17.14.01.0010.000420%
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 10.02.02.004; 01.01.04.001--Not Available
Hepatic steatosis09.01.07.003; 14.08.04.005--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.0020.000105%
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intracranial pressure increased17.07.02.002--Not Available
Jarisch-Herxheimer reaction10.02.01.0020.000105%Not Available
Laryngeal pain22.02.05.036--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.0130.000105%Not Available
Malaise08.01.01.003--
Mass08.03.05.003--Not Available
Menorrhagia21.01.03.002--
Muscle spasms15.05.03.0040.000105%
Musculoskeletal pain15.03.04.007--
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