Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dopamine
Drug ID BADD_D00708
Description One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Indications and Usage For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
Marketing Status Prescription; Discontinued
ATC Code C01CA04
DrugBank ID DB00988
KEGG ID D07870
MeSH ID D004298
PubChem ID 681
TTD Drug ID D0T7OW
NDC Product Code 63083-1515; 55714-9002; 63776-660
Synonyms Dopamine | 4-(2-Aminoethyl)-1,2-benzenediol | Hydroxytyramine | 3,4-Dihydroxyphenethylamine | 3,4 Dihydroxyphenethylamine | Dopamine Hydrochloride | Hydrochloride, Dopamine | Intropin
Chemical Information
Molecular Formula C8H11NO2
CAS Registry Number 51-61-6
SMILES C1=CC(=C(C=C1CCN)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cognitive disorderGlial fibrillary acidic proteinP14136Not Available25644418
Cognitive disorderNitric oxide synthase, inducibleQ06518Not Available25644418
Mental impairment disordersGlial fibrillary acidic proteinP14136Not Available25644418
Mental impairment disordersNitric oxide synthase, inducibleQ06518Not Available25644418
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Piloerection23.02.06.005--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.000097%
Septic shock24.06.02.011; 11.01.11.0040.000097%Not Available
Somnolence19.02.05.003; 17.02.04.0060.000371%
Tachycardia02.03.02.007--Not Available
Vasoconstriction24.04.03.008; 23.06.05.007--Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular tachycardia02.03.04.0100.000371%
Vomiting07.01.07.0030.000556%
Mental status changes19.07.01.0010.000371%Not Available
Tachyarrhythmia02.03.02.0080.000371%Not Available
Acute kidney injury20.01.03.0160.000145%
Multiple organ dysfunction syndrome08.01.03.0570.000097%
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000371%Not Available
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