Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disopyramide
Drug ID BADD_D00693
Description A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Indications and Usage For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Marketing Status Prescription; Discontinued
ATC Code C01BA03
DrugBank ID DB00280
KEGG ID D00303
MeSH ID D004206
PubChem ID 3114
TTD Drug ID D0M4YC
NDC Product Code Not Available
Synonyms Disopyramide | Diisopyramide | Disopyramide Phosphate | Disopyramide Phosphate (1:1) | Disopyramide Phosphate (1:1), (+-)-Isomer | Disopyramide Phosphate (1:1), (R)-Isomer | Disopyramide Phosphate (1:1), (S)-Isomer | Disopyramide, (+-)-Isomer | Disopyramide, (R)-Isomer | Disopyramide, (S)-Isomer | Disopyramide, D-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:1), (R)-Isomer | Disopyramide, L-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:2), (+-)-Isomer | Disopyramide, L-Tartrate, (S)-isomer | Norpace | Palpitin | Palpitine | Rhythmodan | Ritmilen | Rythmilen | SC-13957 | SC 13957 | SC13957 | Disopyramide Monohydrochloride
Chemical Information
Molecular Formula C21H29N3O
CAS Registry Number 3737-09-5
SMILES CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Hepatic enzyme increased13.03.01.019--Not Available
Poisoning12.03.01.004--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Cardiac fibrillation02.03.02.021--Not Available
Psychotic disorder19.03.01.002--
The 4th Page    First    Pre   4    Total 4 Pages