| Drug Name |
Diltiazem hydrochloride |
| Drug ID |
BADD_D00675 |
| Description |
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.[L10556] Compared to dihydropyridine drugs, such as [nifedipine], that preferentially act on vascular smooth muscle and [verapamil] that directly acts on the heart muscle, diltiazem displays an intermediate specificity to target both the cardiac and vascular smooth muscle.[T28] Being a potent vasodilator, diltiazem is used clinically as an antihypertensive, anti-arrhythmic, and as an anti-anginal agent [L6289] for the management of cardiovascular conditions such as hypertension, chronic stable angina, atrial fibrillation, atrial flutter. Apart from its main FDA-approved indications, diltiazem has also been used for numerous off-label indications, such as anal fissures (in topical formulations), migraine prophylaxis, pulmonary hypertension, and rest-related cramps in the lower extremities.[L6289] Typically available in extended-release oral and intravenous formulations, diltiazem is marketed under various brand names with Cardizem and Tiazac being the most common ones. |
| Indications and Usage |
For the treatment of Hypertension |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
C05AE03; C08DB01 |
| DrugBank ID |
DB00343
|
| KEGG ID |
D00616
|
| MeSH ID |
D004110
|
| PubChem ID |
62920
|
| TTD Drug ID |
D0OB1J
|
| NDC Product Code |
42291-187; 68788-7634; 42291-185; 47335-676; 47335-671; 62037-599; 53360-1211; 50090-0451; 68682-371; 71335-1585; 24979-028; 51079-926; 70934-565; 51079-924; 71335-0839; 70771-1035; 15894-0022; 55154-8197; 68682-994; 70771-1037; 71335-0579; 60687-206; 38779-0227; 68981-018; 63304-719; 63187-769; 0187-2045; 0378-6060; 50090-3062; 62991-1046; 0187-2049; 62037-600; 70518-3299; 17478-837; 68071-3264; 52544-693; 50742-251; 70518-3337; 0093-0319; 53360-1214; 50742-252; 68382-746; 71335-1611; 71335-1389; 62037-598; 53360-1213; 47335-670; 17478-937; 68682-006; 62037-698; 63304-721; 72189-344; 0187-0771; 0378-6090; 53360-1212; 65085-0002; 63629-7981; 68682-372; 63304-722; 0187-0772; 0378-6120; 68382-595; 53360-1210; 68682-008; 60505-0015; 70934-564; 0187-0795; 0615-8127; 70771-1033; 70518-0040; 16714-523; 68071-4371; 60687-562; 79572-015; 51754-3000; 47335-675; 42799-131; 50742-248; 68682-007; 71335-1043; 68382-748; 47335-672; 68682-009; 71335-1776; 63629-2154; 55154-8126; 47335-679; 49452-4881; 42799-132; 68462-562; 55154-8140; 70518-1017; 63629-7330; 50742-249; 70771-1031; 71335-1223; 68382-750; 0093-0320; 60687-573; 24979-027; 50090-3124; 58118-1007; 24979-030; 0187-2614; 68682-997; 0187-0796; 0615-8032; 0615-8129; 71335-0634; 50742-250; 68788-7237; 68382-749; 50090-2593; 51079-925; 0187-0792; 0615-8128; 47335-669; 70518-2506; 50090-5466; 0187-0797; 0187-2617; 68462-850; 10370-829; 63629-2153; 70934-854; 0409-4350; 47335-673; 16729-303; 70518-2683; 68382-596; 50090-2870; 63629-7896; 10370-831; 63629-2156; 68682-367; 63629-3649; 70771-1039; 51407-475; 70518-0820; 0187-0799; 52544-694; 68071-3214; 70934-210; 60505-0016; 47335-677; 0187-2050; 16714-524; 68071-3076; 53002-1521; 68682-521; 0615-8381; 24979-029; 62037-700; 0409-1171; 16714-525; 62331-005; 42291-186; 16729-305; 71335-0745; 63304-718; 63629-2159; 70518-1993; 10370-830; 47335-678; 60687-195; 68682-368; 68682-998; 68382-745; 70771-1032; 68462-851; 0641-9219; 0187-2046; 71335-0867; 70860-301; 68071-4005; 70518-2789; 0641-6013; 0615-8379; 0093-0318; 50090-5416; 24979-026; 51407-473; 63629-2158; 63629-2160; 52544-691; 68382-597; 68788-7870; 70934-559; 51754-3500; 71335-1001; 0093-0321; 0187-2048; 0615-8380; 0641-9217; 51407-474; 60687-228; 0187-2612; 71872-7062; 70771-1030; 70771-1036; 70771-1034; 62037-696; 71335-0879; 16729-304; 0395-8110; 68382-747; 42291-184; 0615-8033; 63629-7232; 60505-0014; 68682-369; 42799-129; 68682-993; 42799-130; 12780-2960; 62037-697; 63739-014; 63304-720; 50090-2884; 0228-2918; 63629-2155; 0641-9218; 12828-0037; 71872-7063; 0187-2616; 70771-1040; 60687-217; 68382-599; 68682-370; 52133-0013; 71335-0643; 63629-2157; 62037-597; 0187-2615; 63739-015; 68071-4664; 52544-695; 63629-8232; 71335-2029; 70934-563; 0641-6015; 0187-2047; 55154-8144; 0187-2613; 68071-4591; 70771-1038; 0641-6014; 70518-0109; 71335-0266; 62037-699; 10370-832; 77777-110; 0187-0798; 50090-5452; 68382-598; 63739-016; 71335-1897; 51407-476; 52544-692; 70518-1096; 68071-4242 |
| Synonyms |
Diltiazem | Cardil | Cardizem | CRD-401 | CRD 401 | CRD401 | Tiazac | Dilacor XR | Dilren | Diltiazem Hydrochloride | Diltiazem Malate | Dilzem | Aldizem | Dilacor |
