| Drug Name |
Digoxin |
| Drug ID |
BADD_D00668 |
| Description |
Digoxin is one of the oldest cardiovascular medications used today.[A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure.[A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.[L9143]
This drug originates from the foxglove plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and botanist in the 1780s.[A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai_, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.[A178240] |
| Indications and Usage |
Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients.[L9143] 2) To increase myocardial contraction in children diagnosed with heart failure.[L9143] 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.[L9143]
In adults with heart failure, when it is clinically possible, digoxin should be administered in conjunction with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor for optimum effects.[L9143]
|
| Marketing Status |
approved |
| ATC Code |
C01AA05 |
| DrugBank ID |
DB00390
|
| KEGG ID |
D00298
|
| MeSH ID |
D004077
|
| PubChem ID |
2724385
|
| TTD Drug ID |
D02OZE
|
| NDC Product Code |
82685-202; 42385-101; 69205-201; 57664-437; 59651-436; 70518-2959; 70954-202; 10135-748; 69205-101; 16714-590; 52584-410; 71610-019; 82685-201; 16714-591; 0115-9811; 0115-9822; 50090-5642; 57664-441; 63187-740; 69238-1992; 59212-240; 59651-438; 66689-327; 70515-261; 45085-0101; 69205-202; 0143-1240; 71335-1052; 0143-1241; 50090-5862; 60429-100; 0404-9850; 0054-0057; 69238-1991; 69292-605; 70515-263; 0641-1410; 51927-0291; 51655-403; 59212-242; 59212-249; 60429-099; 70518-3124; 70518-3421; 0615-8202; 0641-6184; 70954-201; 59695-0001; 59695-0002; 55154-5882; 59651-437; 60687-551; 71335-9610; 0904-5921; 51662-1217; 55154-5106; 60687-540; 70515-260; 70515-262; 70954-200; 0781-3059; 0904-5922; 10135-747; 55742-123; 59695-0004 |
| UNII |
73K4184T59
|
| Synonyms |
Digoxin | Lanacordin | Lanicor | Lanoxicaps | Dilanacin | Digacin | Digitek | Digoregen | Digoxina Boehringer | Boehringer, Digoxina | Digoxine Nativelle | Nativelle, Digoxine | Hemigoxine Nativelle | Nativelle, Hemigoxine | Mapluxin | Lanoxin | Lanoxin-PG | Lanoxin PG | Lenoxin |
