Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dicyclomine hydrochloride
Drug ID BADD_D00660
Description Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.[L7982] Dicyclomine was granted FDA approval on 11 May 1950.[L7967]
Indications and Usage including Colicky abdominal pain; diverticulitis
Marketing Status Prescription; Discontinued
ATC Code A03AA07
DrugBank ID DB00804
KEGG ID D00717
MeSH ID D004025
PubChem ID 441344
TTD Drug ID D07XJM
NDC Product Code 70934-682; 61919-324; 51662-1559; 58118-1282; 70518-1767; 0904-6969; 68788-9525; 0603-1161; 68071-3310; 70934-518; 58914-080; 51655-257; 70518-3220; 70934-754; 71335-0425; 67296-1039; 0904-6988; 70436-147; 55289-923; 50090-4681; 50090-0129; 53002-3290; 68083-320; 67296-1409; 70518-1596; 71610-265; 68071-5200; 50090-5454; 63629-8049; 68788-7948; 0517-1980; 60687-369; 63187-196; 0641-6173; 50090-4553; 55700-766; 0527-0586; 50090-0126; 70518-2081; 66267-291; 70518-0302; 67296-0126; 70518-0100; 61919-904; 55700-933; 70625-103; 71335-0938; 0378-1610; 0904-6987; 71610-209; 68071-4782; 43063-045; 63323-842; 43063-629; 55154-3565; 14789-010; 53002-3291; 0054-0622; 0143-1227; 0591-0795; 17337-0015; 55154-8183; 63629-6320; 63629-3341; 63187-784; 17478-015; 50090-2185; 72266-127; 63629-2179; 68788-9705; 70954-261; 70934-649; 68071-3255; 53002-3450; 71205-428; 67296-1050; 51407-365; 31722-963; 70934-519; 50090-1577; 68071-3035; 0591-0794; 70934-182; 0143-3126; 63187-410; 60687-380; 43063-112; 67296-1741; 71335-0471; 49999-081; 68788-7811; 0527-1282; 10135-520; 60760-631; 50090-0128; 17856-0623; 71205-043; 50090-4253; 69037-0069; 50090-0127; 71335-0641; 50090-4677
Synonyms Dicyclomine | Dicycloverin | Dicyclomine Hydrochloride | Hydrochloride, Dicyclomine | Merbentyl | Bentylol | Spascol | Di-Spaz | Di Spaz | Dibent | Diclomin | Lomine | OR-Tyl | OR Tyl | Bentyl | Di-Cyclonex | Di Cyclonex
Chemical Information
Molecular Formula C19H36ClNO2
CAS Registry Number 67-92-5
SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Apnoea22.02.01.001--
Asphyxia22.02.02.001; 12.01.08.011--Not Available
Asthenia08.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dyspnoea22.02.01.004; 02.01.03.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Hypohidrosis08.01.03.029; 23.02.03.005--
Insomnia19.02.01.002; 17.15.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Pruritus23.03.12.001--
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