Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desflurane
Drug ID BADD_D00611
Description Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as [methoxyflurane], [sevoflurane], [enflurane], or [isoflurane].[A226390,A39015,A226893]. It was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.[A226883,A226888] Desflurane was granted FDA approval on 18 September 1992.[L30285]
Indications and Usage For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
Marketing Status Prescription
ATC Code N01AB07
DrugBank ID DB01189
KEGG ID D00546
MeSH ID D000077335
PubChem ID 42113
TTD Drug ID D0H4GN
NDC Product Code 10019-644; 0781-6172; 52584-641; 10019-641; 0404-9961; 57884-0028; 10019-646
Synonyms Desflurane | 1,2,2,2-Tetrafluoroethyl difluoromethyl ether | I 653 | I-653 | I653 | Suprane
Chemical Information
Molecular Formula C3H2F6O
CAS Registry Number 57041-67-5
SMILES C(C(F)(F)F)(OC(F)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
NeuritisTransient receptor potential cation channel subfamily V member 1Q704Y3Not Available25517196
NeuritisTransient receptor potential cation channel subfamily A member 1Q8BLA8Not Available25517196
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypercapnia22.02.02.002; 14.01.04.001--Not Available
Hyperkalaemia14.05.03.001--
Hypertension24.08.02.001--
Hyperthermia malignant08.05.01.0020.001028%Not Available
Hypokalaemia14.05.03.002--
Hypotension24.06.03.0020.001182%
Hypoxia22.02.02.003--
Infection11.01.08.002--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Keratitis06.04.02.002--
Laryngospasm22.04.02.002--
Light anaesthesia25.01.03.003--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Malaise08.01.01.003--
Malignant hypertension24.08.01.002--Not Available
Metabolic acidosis14.01.01.003--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nodal arrhythmia02.03.02.005--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oxygen saturation decreased13.02.01.0040.001182%Not Available
Palpitations02.01.02.003--
Pancreatitis acute07.18.01.002--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
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