Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Deoxycholic acid
Drug ID BADD_D00609
Description Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic appearance and reduce facial fullness or convexity. It is marketed under the brand name Kybella by Kythera Biopharma and is the first pharmacological agent available for submental fat reduction, allowing for a safer and less invasive alternative than surgical procedures.
Indications and Usage For improvement in appearance of moderate to severe fullness associated with submental fat in adults.
Marketing Status approved
ATC Code D11AX24
DrugBank ID DB03619
KEGG ID D10781
MeSH ID D003840
PubChem ID 222528
TTD Drug ID Not Available
NDC Product Code 61168-101; 66039-937; 50384-0151
UNII 005990WHZZ
Synonyms Deoxycholic Acid | Desoxycholic Acid | Dihydroxycholanoic Acid | Choleic Acid | Deoxycholate | Deoxycholic Acid, 12beta-Isomer | 12beta-Isomer Deoxycholic Acid | Deoxycholic Acid, 12beta Isomer | Deoxycholic Acid, 3beta-Isomer | 3beta-Isomer Deoxycholic Acid | Deoxycholic Acid, 3beta Isomer | Deoxycholic Acid, 5alpha-Isomer | 5alpha-Isomer Deoxycholic Acid | Deoxycholic Acid, 5alpha Isomer | Deoxycholic Acid, Magnesium (2:1) Salt | Deoxycholic Acid, Monoammonium Salt | Deoxycholic Acid, Monopotassium Salt | Deoxycholic Acid, Monosodium Salt | Sodium Deoxycholate | Deoxycholate, Sodium | Deoxycholic Acid, Sodium Salt, 12beta-Isomer | Lagodeoxycholic Acid | Kybella | Deoxycholic Acid, Disodium Salt
Chemical Information
Molecular Formula C24H40O4
CAS Registry Number 83-44-3
SMILES CC(CCC(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear discomfort04.03.01.0050.000603%Not Available
Musculoskeletal stiffness15.03.05.0270.000904%Not Available
Injection site swelling12.07.03.018; 08.02.03.0170.028302%Not Available
Infusion site warmth12.07.05.012; 08.02.05.011--Not Available
Vascular occlusion24.04.02.0150.001046%Not Available
Nodule08.03.05.0020.004008%Not Available
Injection site discomfort12.07.03.019; 08.02.03.0180.001383%Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.0040.000603%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.002802%Not Available
Paraesthesia oral07.05.05.035; 17.02.06.0080.002412%Not Available
Injection site nodule08.02.03.034; 23.07.04.009; 12.07.03.0340.013867%Not Available
Injection site scar23.03.11.016; 12.07.03.050; 08.02.03.0500.000603%Not Available
Induration08.01.03.0200.002199%Not Available
Inflammation08.01.05.007; 10.02.01.0890.001206%Not Available
Sensation of foreign body08.01.09.0020.000603%Not Available
Injection site pallor12.07.03.048; 08.02.03.048; 23.03.03.0570.000266%Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.001206%
Injection site exfoliation12.07.03.030; 08.02.03.030; 23.03.07.0080.000603%Not Available
Mouth swelling23.04.01.020; 10.01.05.020; 07.05.04.0070.000904%Not Available
Nipple exudate bloody24.07.03.032; 21.05.05.0150.000603%Not Available
Post inflammatory pigmentation change23.05.03.0020.000904%Not Available
Neck mass15.03.02.0070.000603%Not Available
Facial asymmetry15.10.05.0040.004220%Not Available
Administration site induration12.07.04.022; 08.02.04.0220.000603%Not Available
Administration site scab23.03.03.072; 12.07.04.031; 08.02.04.0310.000603%Not Available
Application site bruise08.02.01.048; 24.07.06.026; 23.03.11.026; 12.07.01.0480.000603%Not Available
Drug ineffective for unapproved indication12.09.02.002; 08.06.01.0380.002412%Not Available
Excessive skin23.03.03.0780.000603%Not Available
Injection site alopecia23.02.02.012; 12.07.03.054; 08.02.03.0540.000603%Not Available
Injection site deformation12.07.03.056; 08.02.03.0560.000603%Not Available
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