| Pharmaceutical Information |
| Drug Name |
Defibrotide sodium |
| Drug ID |
BADD_D00598 |
| Description |
Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. In the USA it is was approved in March, 2016 as Defitelio. |
| Indications and Usage |
Defibrotide is used to treat or prevent a failure of normal blood flow (occlusive venous disease, OVD) in the liver of patients who have had bone marrow transplants or received certain drugs such as oral estrogens, mercaptopurine, and many others. |
| Marketing Status |
Prescription |
| ATC Code |
B01AX01 |
| DrugBank ID |
DB04932
|
| KEGG ID |
D07423
|
| MeSH ID |
C036901
|
| PubChem ID |
135565962
|
| TTD Drug ID |
D0FM2W
|
| NDC Product Code |
68727-800; 68225-107 |
| Synonyms |
defibrotide | defibrotide (bovine) | defibrinotide | defibrotide sodium | defibrotide sodium (porcine mucosa) | JZP-381 | JZP381 | Defitelio |
|
| Chemical Information |
| Molecular Formula |
C20H21N4O6P |
| CAS Registry Number |
83712-60-1 |
| SMILES |
CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)OP(=O)(O)O |
| Chemical Structure |
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|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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