Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferoxamine
Drug ID BADD_D00596
Description Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Indications and Usage Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions.
Marketing Status Prescription; Discontinued
ATC Code V03AC01
DrugBank ID DB00746
KEGG ID D03670
MeSH ID D003676
PubChem ID 2973
TTD Drug ID D0FJ8A
NDC Product Code Not Available
Synonyms Deferoxamine | Desferrioxamine | Desferioximine | Deferoxamine B | Desferrioxamine B | Deferoximine | Deferrioxamine B | Desferroxamine | Desferrioxamine B Mesylate | Mesylate, Desferrioxamine B | Deferoxamine Mesilate | Mesilate, Deferoxamine | Deferoxamine Mesylate | Mesylate, Deferoxamine | Deferoxamine Methanesulfonate | Methanesulfonate, Deferoxamine | Desferal
Chemical Information
Molecular Formula C25H48N6O8
CAS Registry Number 70-51-9
SMILES CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.005831%Not Available
Abdominal pain07.01.05.0020.011662%
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.001521%Not Available
Acute respiratory distress syndrome22.01.03.001--
Alanine aminotransferase increased13.03.01.0030.005831%
Anaemia01.03.02.0010.014578%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Arrhythmia02.03.02.0010.005831%Not Available
Arthralgia15.01.02.0010.005831%
Asthenia08.01.01.0010.008747%Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Blindness17.17.01.003; 06.02.02.0010.008747%Not Available
Blood creatinine increased13.13.01.0040.002282%
Blood glucose increased13.02.02.0020.005831%Not Available
Blood iron increased13.11.01.0070.005831%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.005831%
Blood pressure decreased13.14.03.0020.005831%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.0020.005831%Not Available
C-reactive protein increased13.09.01.0070.003042%Not Available
Cardiac arrest02.03.04.0010.001521%
Cardiac failure02.05.01.0010.003803%
Cardiac failure congestive02.05.01.0020.008747%Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.0010.008747%Not Available
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