Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferiprone
Drug ID BADD_D00595
Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indications and Usage Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Marketing Status Prescription
ATC Code V03AC02
DrugBank ID DB08826
KEGG ID D07416
MeSH ID D000077543
PubChem ID 2972
TTD Drug ID D0N0OU
NDC Product Code 10122-101; 10122-103; 0054-0576; 52609-0006; 17349-0023; 10122-104; 0054-0711; 10122-100; 51672-7502; 52609-4502; 51672-4196; 52609-0007
Synonyms Deferiprone | 1,2-Dimethyl-3-hydroxy-4-pyridinone | 1,2 Dimethyl 3 hydroxy 4 pyridinone | DMOHPO | 1,2-Dimethyl-3-hydroxypyrid-4-one | 1,2 Dimethyl 3 hydroxypyrid 4 one | 3-Hydroxy-1,2-dimethyl-4-pyridinone | 3 Hydroxy 1,2 dimethyl 4 pyridinone | HDMPP | 1,2-Dimethyl-3-hydroxypyridin-4-one | 1,2 Dimethyl 3 hydroxypyridin 4 one | Ferriprox
Chemical Information
Molecular Formula C7H9NO2
CAS Registry Number 30652-11-0
SMILES CC1=C(C(=O)C=CN1C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disability26.01.01.003--Not Available
Discomfort08.01.08.003--Not Available
Dyspepsia07.01.02.001--
Encephalitis17.06.05.001; 11.01.03.008--
Encephalitis viral17.06.06.002; 11.05.04.010--Not Available
Enterocolitis07.08.03.003--
Epistaxis24.07.01.005; 22.04.03.001--
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.0020.020409%
Febrile neutropenia08.05.02.004; 01.02.03.0020.017494%
Fibrosis08.03.01.001--Not Available
Furuncle23.09.01.004; 11.02.05.008--Not Available
Gait disturbance17.02.05.016; 08.01.02.002--
Gastric ulcer07.04.03.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glycosuria20.02.01.005--
Haemoglobinuria20.02.01.017; 01.06.04.005--
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Headache17.14.01.001--
Henoch-Schonlein purpura10.02.02.004; 01.01.04.001; 24.07.06.003; 23.06.01.002--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis C11.05.06.004; 09.01.09.005--Not Available
Hepatitis infectious11.01.18.004; 09.01.09.006--Not Available
Hepatomegaly09.01.05.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
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