Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary hypertension22.06.01.001; 24.08.03.0020.005907%
Pulmonary oedema22.01.03.003; 02.05.02.0030.034900%
Pulmonary tuberculosis22.07.06.002; 11.04.01.0030.000799%Not Available
Pyrexia08.05.02.0030.029838%
Rash23.03.13.0010.067402%Not Available
Rash erythematous23.03.06.003--Not Available
Rash follicular23.03.10.001--Not Available
Rash generalised23.03.13.002--Not Available
Rash macular23.03.13.0030.001332%Not Available
Rash maculo-papular23.03.13.004--
Rash papular23.03.13.0170.001066%Not Available
Rash pruritic23.03.12.002--Not Available
Rash pustular23.03.10.003; 11.01.12.002--
Rash vesicular23.03.13.009--Not Available
Raynaud's phenomenon24.04.03.0030.001598%Not Available
Rectal cancer16.13.01.003; 07.21.05.0020.000139%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rectal polyp16.05.02.003; 07.20.01.0050.000533%Not Available
Red blood cell count decreased13.01.05.0070.004529%Not Available
Renal disorder20.01.02.0020.003463%Not Available
Renal failure20.01.03.005--Not Available
Renal tubular disorder20.05.03.0040.000533%Not Available
Respiratory disorder22.02.07.0020.003996%Not Available
Respiratory distress22.02.01.0120.002664%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retching07.01.07.0020.001066%Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.0010.001865%Not Available
Retinopathy24.03.07.003; 06.10.02.0010.000533%
Rhabdomyolysis15.05.05.002--
Rhinorrhoea22.02.05.0100.003996%
The 18th Page    First    Pre   18 19 20 21 22    Next   Last    Total 30 Pages