Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Photophobia17.17.02.006; 06.01.01.0040.001066%
Photosensitivity reaction23.03.09.0030.001865%
Plasma cell myeloma16.23.02.004; 01.14.02.004--Not Available
Platelet count abnormal13.01.04.0050.000533%Not Available
Platelet count decreased13.01.04.0010.020247%
Platelet disorder01.08.03.0010.000533%Not Available
Pleural effusion22.05.02.0020.156650%
Pleural fibrosis22.05.03.0030.000799%Not Available
Pleurisy22.05.01.0010.005861%Not Available
Pneumonia22.07.01.003; 11.01.09.0030.025575%Not Available
Pneumonia aspiration22.01.01.005--Not Available
Pneumonia cytomegaloviral22.07.05.001; 11.05.01.0010.000533%Not Available
Pneumonia viral22.07.05.006; 11.05.04.0240.000208%Not Available
Pneumonitis22.01.01.006--
Pneumothorax22.05.02.0030.001332%
Pollakiuria20.02.02.007--
Polycythaemia01.07.01.0010.000533%Not Available
Polyneuropathy17.09.03.0120.000799%Not Available
Polyserositis08.01.05.0030.001066%Not Available
Premature baby18.04.02.001--Not Available
Premature delivery18.07.01.006--
Premature menopause21.02.02.004; 05.05.01.0160.000799%
Productive cough22.02.03.0050.002664%
Proteinuria20.02.01.011--
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.001--
Psoriasis23.03.14.002; 10.02.01.036--Not Available
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.0020.000486%Not Available
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Pulmonary fibrosis22.01.02.006--
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