Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapsone
Drug ID BADD_D00580
Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Indications and Usage For the treatment and management of leprosy and dermatitis herpetiformis.
Marketing Status Prescription
ATC Code D10AX05; J04BA02
DrugBank ID DB00250
KEGG ID D00592
MeSH ID D003622
PubChem ID 2955
TTD Drug ID D0MA9N
NDC Product Code 51927-0084; 70954-135; 49938-102; 65571-0021; 51552-1042; 46438-0645; 49938-101; 49452-2439; 43353-222; 16110-367; 76072-1018; 51927-4368; 53596-014; 70954-136; 58159-033; 51927-0083; 60758-670; 60429-496; 60429-495; 0904-7018; 43353-223; 14474-026; 16714-956; 71052-100; 50218-008; 51672-4197; 29967-0007; 51672-4198; 14474-038; 0023-3670; 0023-5206; 68308-342; 10695-047; 51672-1388; 45562-1120; 51927-0085; 73309-094; 13668-605; 51672-1387; 29033-036; 29033-037; 16110-526; 51672-5307; 0904-7019; 72375-0006
Synonyms Dapsone | DADPS | Sulfonyldianiline | Diaminodiphenylsulfone | Diaphenylsulfone | 4,4'-Diaminophenyl Sulfone | 4,4' Diaminophenyl Sulfone | Sulfone, 4,4'-Diaminophenyl | Sulfona | Dapson-Fatol | Disulone | Avlosulfone | Dapsoderm-X
Chemical Information
Molecular Formula C12H12N2O2S
CAS Registry Number 80-08-0
SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AgranulocytosisMyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
HypersensitivityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Lupus erythematosus (incl subtypes)MyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.0020.001603%Not Available
Pemphigus23.03.01.005; 10.04.02.0030.001603%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pleural effusion22.05.02.0020.003207%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonitis22.01.01.0060.002405%
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.004810%
Pulmonary eosinophilia22.01.01.009; 01.02.04.006--Not Available
Pyrexia08.05.02.0030.008819%
Rash23.03.13.0010.011224%Not Available
Rash erythematous23.03.06.0030.002405%Not Available
Rash maculo-papular23.03.13.0040.001603%
Renal failure20.01.03.0050.001046%Not Available
Renal papillary necrosis20.01.07.002; 14.07.02.001; 05.07.02.001--Not Available
Respiratory distress22.02.01.0120.003207%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001882%
Reticulocyte count increased13.01.05.010--Not Available
Rosacea23.02.08.0010.001603%Not Available
Scratch23.03.11.017; 12.01.06.0090.001603%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.0030.001255%
Septic shock24.06.02.011; 11.01.11.0040.000418%Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin discolouration23.03.03.0050.004810%Not Available
Skin disorder23.03.03.0070.002405%Not Available
Skin exfoliation23.03.07.0030.010422%Not Available
Skin irritation23.03.04.0090.003207%Not Available
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