Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
TTD Drug ID D01TNW
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia07.14.03.001; 17.02.07.003--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.0020.004220%
Epididymitis21.09.02.001; 11.01.19.0050.001206%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling jittery08.01.09.0160.001206%Not Available
Flank pain15.03.04.003; 08.01.08.007; 20.02.03.0060.003015%
Fracture15.08.02.001; 12.04.02.001--
Fungal infection11.03.05.0010.071747%Not Available
Fungal skin infection11.03.05.002; 23.09.02.0010.001809%Not Available
Gangrene24.04.05.003; 23.06.06.001; 11.02.01.0030.003015%Not Available
Gastroenteritis11.01.07.004; 07.19.03.0010.001809%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Genital candidiasis11.03.03.002; 21.10.03.001--Not Available
Genital rash23.03.13.016; 21.10.01.0090.004823%Not Available
Glomerular filtration rate decreased13.13.01.0090.006029%Not Available
Glycosuria20.02.01.0050.004220%
Glucose urine present13.13.02.0010.004220%Not Available
Glycosylated haemoglobin decreased13.02.02.0120.001206%Not Available
Glycosylated haemoglobin increased13.02.02.0050.018690%Not Available
Gout15.01.06.001; 14.09.01.0010.001206%Not Available
Granuloma annulare23.03.15.0050.001206%Not Available
Haematocrit increased13.01.05.0020.001206%Not Available
Haematuria20.02.01.006; 24.07.01.0470.012661%
Blood urine present13.13.02.0020.002412%Not Available
Headache17.14.01.001--
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